The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, China.
J Zhejiang Univ Sci B. 2020;21(10):767-778. doi: 10.1631/jzus.B2000245.
RNA helicases, the largest family of proteins that participate in RNA metabolism, stabilize the intracellular environment through various processes, such as translation and pre-RNA splicing. These proteins are also involved in some diseases, such as cancers and viral diseases. Autophagy, a self-digestive and cytoprotective trafficking process in which superfluous organelles and cellular garbage are degraded to stabilize the internal environment or maintain basic cellular survival, is associated with human diseases. Interestingly, similar to autophagy, RNA helicases play important roles in maintaining cellular homeostasis and are related to many types of diseases. According to recent studies, RNA helicases are closely related to autophagy, participate in regulating autophagy, or serve as a bridge between autophagy and other cellular activities that widely regulate some pathophysiological processes or the development and progression of diseases. Here, we summarize the most recent studies to understand how RNA helicases function as regulatory proteins and determine their association with autophagy in various diseases.
RNA 解旋酶是参与 RNA 代谢的最大蛋白家族之一，通过翻译和前 RNA 剪接等多种过程稳定细胞内环境。这些蛋白质也与一些疾病有关，如癌症和病毒疾病。自噬是一种自我消化和细胞保护的运输过程，其中多余的细胞器和细胞垃圾被降解，以稳定内部环境或维持基本的细胞存活，与人类疾病有关。有趣的是，与自噬类似，RNA 解旋酶在维持细胞内稳态方面发挥着重要作用，并与许多类型的疾病有关。根据最近的研究，RNA 解旋酶与自噬密切相关，参与调节自噬，或作为自噬与其他广泛调节一些病理生理过程或疾病发展和进展的细胞活动之间的桥梁。在这里，我们总结了最近的研究，以了解 RNA 解旋酶如何作为调节蛋白发挥作用，并确定它们在各种疾病中与自噬的关联。
