Boon N A, Frew A J, Johnston J A, Cobbe S M
Br Heart J. 1987 Jul;58(1):34-9. doi: 10.1136/hrt.58.1.34.
Fifteen patients with dual chamber pacemakers implanted for atrioventricular block (11) or sinoatrial disease (4) completed a single blind within-patient comparison of symptoms and 24 hour intra-arterial blood pressure during long term atrioventricular synchronous (DDD) pacing and long term ventricular demand (VVI) pacing. The patients reported significantly less breathlessness, fatigue, and dizziness and a significantly greater sense of general well-being during DDD pacing than during VVI pacing. Twelve of the fifteen patients expressed a strong preference for DDD pacing. Systolic blood pressure tended to be lower and was significantly more variable during VVI pacing than during DDD pacing (mean (SD) daytime systolic blood pressure 132.4 (17.1) and 140.4 (13.1) mm Hg respectively). Accordingly, episodes of hypotension were more common during VVI pacing, which may partly explain why the patients reported more symptoms during this mode of pacing.
15例因房室传导阻滞（11例）或窦房结疾病（4例）而植入双腔起搏器的患者，完成了一项单盲的自身对照研究，比较了长期房室同步（DDD）起搏和长期心室按需（VVI）起搏期间的症状及24小时动脉内血压。与VVI起搏相比，患者在DDD起搏期间报告的呼吸困难、疲劳和头晕明显更少，总体幸福感明显更强。15例患者中有12例强烈倾向于DDD起搏。与DDD起搏相比，VVI起搏期间收缩压往往更低，且变异性明显更大（平均（标准差）日间收缩压分别为132.4（17.1）和140.4（13.1）mmHg）。因此，VVI起搏期间低血压发作更常见，这可能部分解释了为什么患者在这种起搏模式下报告的症状更多。
