College of Pharmacy and Traditional Chinese Medicine, Jiangsu College of Nursing, Huaian, Jiangsu, 223005, China.
College of Pharmacy and Traditional Chinese Medicine, Jiangsu College of Nursing, Huaian, Jiangsu, 223005, China.
Biochem Pharmacol. 2024 Jun;224:116218. doi: 10.1016/j.bcp.2024.116218. Epub 2024 Apr 21.
Non-coding RNAs (ncRNAs) are an assorted collection of transcripts that are not translated into proteins. Since their discovery, ncRNAs have gained prominence as crucial regulators of various biological functions across diverse cell types and tissues, and their abnormal functioning has been implicated in disease. Notably, extensive research has focused on the relationship between microRNAs (miRNAs) and human cancers, although other types of ncRNAs, such as long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), are also emerging as significant contributors to human disease. In this review, we provide a comprehensive summary of our current knowledge regarding the roles of miRNAs, lncRNAs, and circRNAs in cancer and other major human diseases, particularly cancer, cardiovascular, neurological, and infectious diseases. Moreover, we discuss the potential utilization of ncRNAs as disease biomarkers and as targets for therapeutic interventions.
非编码 RNA（ncRNA）是一类不翻译成蛋白质的转录本。自发现以来，ncRNA 已成为不同细胞类型和组织中各种生物功能的关键调节剂，其异常功能与疾病有关。值得注意的是，大量研究集中在 microRNAs（miRNAs）与人类癌症之间的关系上，尽管其他类型的 ncRNA，如长非编码 RNA（lncRNA）和环状 RNA（circRNA），也被认为是人类疾病的重要贡献者。在这篇综述中，我们全面总结了目前关于 miRNAs、lncRNAs 和 circRNAs 在癌症和其他主要人类疾病（特别是癌症、心血管、神经和传染病）中的作用的知识。此外，我们还讨论了将 ncRNA 用作疾病生物标志物和治疗干预靶点的潜力。
