School of Psychology, Army Medical University, Chongqing, China.
Department of Psychological and Psychological Medicine, The 958th Hospital of the Chinese People's Liberation Army, Chongqing, China.
BMC Psychiatry. 2020 Oct 12;20(1):501. doi: 10.1186/s12888-020-02877-6.
Childhood trauma and over-general autobiographical memory (OGM) are crucial risk factors of suicide. This study aimed to investigate whether suicidal ideation was predicted by one's childhood trauma and OGM and the mechanism of OGM underlying suicidal ideation in depression patients and healthy controls.
A total of 180 depression patients and 176 matched healthy individuals were recruited in this study. Data were analyzed using descriptive statistics, and Pearson's correlation coefficient was obtained. Path analysis was conducted to test a meditational model. The multigroup comparison was applied to find differences between groups.
Significant differences were detected between depression patients and healthy controls with respect to childhood trauma, OGM, suicidal ideation, and suicidal behavior. OGM was positively correlated with both current and worst-point suicidal ideation in the depression group and significantly correlated with worst-point suicidal ideation in the healthy control group. The path model showed that childhood trauma had a direct impact on the current suicidal ideation directly, and an indirect influence through OGM and worst-point suicidal ideation. Multigroup analysis further demonstrated that OGM affected and mediated the current suicidal ideation due to childhood trauma in depression patients, whereas only worst-point suicidal ideation was affected in healthy controls.
The OGM mediates suicidal ideation in depression patients, but only affects the worst-point suicidal ideation in the healthy controls. As it is one of the major risk factors of suicidal ideation in depression, amelioration of OGM might be an useful method to reduce or prevent suicidal ideation in depression patients.
童年创伤和自传体记忆概括（OGM）过度是自杀的重要风险因素。本研究旨在探讨抑郁患者和健康对照者中，自杀意念是否由童年创伤和 OGM 预测，以及 OGM 对自杀意念的潜在机制。
本研究共招募了 180 名抑郁患者和 176 名匹配的健康个体。使用描述性统计和 Pearson 相关系数进行数据分析。采用路径分析检验中介模型。应用多组比较寻找组间差异。
抑郁患者和健康对照者在童年创伤、OGM、自杀意念和自杀行为方面存在显著差异。OGM 与抑郁组当前和最差点自杀意念呈正相关，与健康对照组最差点自杀意念呈显著相关。路径模型显示，童年创伤对当前自杀意念有直接影响，也通过 OGM 和最差点自杀意念产生间接影响。多组分析进一步表明，OGM 影响并通过最差点自杀意念介导了抑郁患者的当前自杀意念，而在健康对照组中仅影响最差点自杀意念。
OGM 中介了抑郁患者的自杀意念，但仅影响健康对照组的最差点自杀意念。作为抑郁患者自杀意念的主要风险因素之一，改善 OGM 可能是减少或预防抑郁患者自杀意念的有效方法。
