Altamimi Alhanouf F, Alqahtani Zuhour A, Alshiha Kholoud A, Almughaiseeb Fay, Alfayez Norah F, Alkhatir Alexandra A
Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, SAU.
Obstetrics and Gynaecology, Imam Mohammad Ibn Saud Islamic University, Riyadh, SAU.
Cureus. 2020 Sep 6;12(9):e10284. doi: 10.7759/cureus.10284.
Obesity is one of the most common risk factors for polycystic ovarian syndrome (PCOS). Reducing body weight has shown to improve the symptoms of PCOS; however, it is still unclear if the surgical treatment of obesity can have better outcomes to control obesity and improve PCOS.
This study aims to identify the impact of sleeve gastrectomy on PCOS symptoms in Riyadh, Saudi Arabia with a comparison of other weight reduction surgeries.
This is a prospective study that included patients with PCOS who had weight reduction surgeries between 2018 and 2020, in Riyadh, Saudi Arabia. Using an online questionnaire, demographic data will be collected and information about menstruation, abortion, polycystic ovarian syndrome, and bariatric surgeries (if any). Data analysis was done through Statistical Package for the Social Sciences (SPSS) v26 (IBM Corp., Armonk, NY, USA).
Ninety-nine female patients responded to this survey, all of whom had PCOS; 57.6% of these patients had a positive family history of PCOS. The most-reported PCOS symptoms were irregular menses (63.6%) and weight gain (53.5%), while 9.1% were asymptomatic. 52.5% were obese, and 91.1% underwent gastric sleeve surgery to treat their obesity. 41.4% of the females had a regular cycle before the operation, which increased to 60.6% after the operation; 48.5% had a normal flow before the operation, which increased to 61.6% after the operation. 15.2% conceived once before the operation, which increased to 16.2% after the operation. 11.1% had one abortion before surgery, which decreased to 7.1% after surgery. 55.6% observed an improvement in their PCOS symptoms after surgery, and 47.5% found that their fertility improved according to their own perception. Females with a positive family history of PCOS had a higher prevalence of PCOS (p-value <0.001). Also, females 30-39 years old are significantly more likely to have PCOS (p-value <0.001). The incidence of abnormal menstrual flow and irregular menstrual cycle was seen significantly more in PCOS patients than non-PCOS (p-value=0.019 and 0.004, respectively). PCOS symptoms and fertility significantly improved after surgery (p-value=0.031 and 0.043, respectively).
Sleeve gastrectomy can lead to significant improvement in fertility and symptoms of PCOS. It can also reduce the incidence of abortion. Other surgical techniques should be investigated.
肥胖是多囊卵巢综合征（PCOS）最常见的危险因素之一。减轻体重已显示可改善PCOS症状；然而，肥胖的手术治疗是否能更好地控制肥胖并改善PCOS仍不清楚。
本研究旨在确定沙特阿拉伯利雅得市袖状胃切除术对PCOS症状的影响，并与其他减肥手术进行比较。
这是一项前瞻性研究，纳入了2018年至2020年期间在沙特阿拉伯利雅得市接受减肥手术的PCOS患者。通过在线问卷收集人口统计学数据以及有关月经、流产、多囊卵巢综合征和减肥手术（如有）的信息。数据分析通过社会科学统计软件包（SPSS）v26（美国纽约州阿蒙克市IBM公司）完成。
99名女性患者回复了此项调查，她们均患有PCOS；其中57.6%的患者有PCOS家族史。最常报告的PCOS症状是月经不规律（63.6%）和体重增加（53.5%），而9.1%的患者无症状。52.5%的患者肥胖，91.1%的患者接受了袖状胃切除术来治疗肥胖。41.4%的女性在手术前月经周期规律，术后增至60.6%；48.5%的女性在手术前月经量正常，术后增至61.6%。15.2%的女性在手术前曾怀孕一次，术后增至16.2%。11.1%的女性在手术前有过一次流产，术后降至7.1%。55.6%的患者术后PCOS症状有所改善，47.5%的患者自认为生育能力有所提高。有PCOS家族史的女性患PCOS的患病率更高（p值<0.001）。此外，30 - 39岁的女性患PCOS的可能性显著更高（p值<0.001）。PCOS患者月经流量异常和月经周期不规律的发生率显著高于非PCOS患者（p值分别为0.019和0.004）。手术后PCOS症状和生育能力显著改善（p值分别为0.031和0.043）。
袖状胃切除术可显著改善PCOS患者的生育能力和症状，还可降低流产发生率。应研究其他手术技术。
