Halonen Pia, Jakobsson Maija, Heikinheimo Oskari, Gissler Mika, Pukkala Eero
Department of Obstetrics and Gynecology, HUCH Hyvinkää Hospital, FI-05850 Hyvinkää, Finland. E-mail:
Acta Derm Venereol. 2020 Oct 28;100(17):adv00303. doi: 10.2340/00015555-3664.
The incidence pattern of lichen planus (LP) and LP-related mortality are unknown. The aim of this study was to assess these factors, based on Finnish nationwide registry data including 13,378 women with LP diagnosed during 1969 to 2012. The incidence rate for LP in 2003 to 2012 was 28 per 100,000 woman-years age-adjusted to the European Standard Population. Mortality was assessed using the standardized mortality ratio (SMR) with national mortality rates as the reference. All-cause mortality was increased (SMR 1.07, 95% confidence interval (95% CI) 1.02-1.11), with excess mortality from Hodgkin lymphoma (SMR 6.73, 95% CI 1.83-17.2), non-Hodgkin lymphoma (SMR 1.68, 95% CI 1.11-2.44), cancer of the oral cavity (SMR 10.5, 95% CI 5.99-17.0), cancer of the tongue (SMR 7.25, 95% CI 3.13-14.3), infections (SMR 1.78, 95% CI 1.14-2.64), respiratory diseases (SMR 1.31, 95% CI 1.07-1.57), and diseases of the digestive system (SMR 1.39, 95% CI 1.09-1.75). In conclusion, LP is a common disease and patients seem to have an impaired long-term prognosis.
扁平苔藓（LP）的发病模式及与LP相关的死亡率尚不清楚。本研究旨在基于芬兰全国登记数据评估这些因素，该数据涵盖了1969年至2012年期间确诊的13378例LP女性患者。2003年至2012年期间，LP的发病率经年龄调整后为每100,000女性年28例，以欧洲标准人口为参照。死亡率评估采用标准化死亡比（SMR），以全国死亡率作为参考。全因死亡率升高（SMR 1.07，95%置信区间（95%CI）1.02 - 1.11），霍奇金淋巴瘤（SMR 6.73，95%CI 1.83 - 17.2）、非霍奇金淋巴瘤（SMR 1.68，95%CI 1.11 - 2.44）、口腔癌（SMR 10.5，95%CI 5.99 - 17.0）、舌癌（SMR 7.25，95%CI 3.13 - 14.3）、感染（SMR 1.78，95%CI 1.14 - 2.64）、呼吸系统疾病（SMR 1.31，95%CI 1.07 - 1.57）及消化系统疾病（SMR 1.39，95%CI 1.09 - 1.75）导致的死亡率均过高。总之，LP是一种常见疾病，患者的长期预后似乎较差。
