Department of Medical Technology, Cangzhou Medical College, Cangzhou, 061001, People's Republic of China.
Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of life Science and technology, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Brain Imaging Behav. 2021 Aug;15(4):2101-2108. doi: 10.1007/s11682-020-00405-4. Epub 2020 Oct 13.
Amyotrophic lateral sclerosis (ALS) is a multi-system disease featured by movement disorder. Studies on ALS using static neuroimaging indexes demonstrated inconsistent results. However, recent work indicated that the intrinsic brain activity was time-varying, and the abnormal temporal dynamics of brain activity in ALS remains unknown. Resting-state functional magnetic resonance imaging data were first obtained from 54 patients with ALS and 54 healthy controls (HCs). Then the dynamic regional homogeneity (d-ReHo) was calculated and compared between the two groups. Correlation analyses between altered d-ReHo and clinical scores were further performed. Compared with HCs, ALS patients showed higher d-ReHo in the left lingual gyrus while lower d-ReHo in the left rectus gyrus and left parahippocampal gyrus. Moreover, the d-ReHo in the left lingual gyrus exhibited correlation with disease progression rate in ALS at a trend level. Our findings suggested that altered dynamics in intrinsic brain activity might be a potential biomarker for diagnosing of ALS.
肌萎缩侧索硬化症（ALS）是一种以运动障碍为特征的多系统疾病。使用静态神经影像学指标对 ALS 的研究结果不一致。然而，最近的研究表明，大脑的内在活动是时变的，ALS 患者大脑活动的异常时间动力学尚不清楚。首先从 54 例 ALS 患者和 54 例健康对照者（HCs）中获得静息态功能磁共振成像数据。然后计算并比较两组的动态局部一致性（d-ReHo）。进一步对改变的 d-ReHo 与临床评分之间的相关性进行分析。与 HCs 相比，ALS 患者左侧舌回的 d-ReHo 升高，而左侧直回和左侧海马旁回的 d-ReHo 降低。此外，左侧舌回的 d-ReHo 与 ALS 患者的疾病进展率呈趋势相关。我们的研究结果表明，内在脑活动的改变可能是诊断 ALS 的潜在生物标志物。
