Spine Center, Hessing Foundation, Hessingstrasse 17, 86199, Augsburg, Germany.
Center of Orthopaedic and Trauma Surgery, Philipps University of Marburg, Baldingerstrasse, 35043, Marburg, Germany.
Eur Spine J. 2021 Aug;30(8):2176-2184. doi: 10.1007/s00586-020-06613-2. Epub 2020 Oct 13.
Apart from patients with severe neurological deficits, it is not clear whether surgical or conservative treatment of lumbar disc herniations is superior for the individual patient. We investigated whether deep learning techniques can predict the outcome of patients with lumbar disc herniation after 6 months of treatment.
The data of 60 patients were used to train and test a deep learning algorithm with the aim to achieve an accurate prediction of the ODI 6 months after surgery or the start of conservative therapy. We developed an algorithm that predicts the ODI of 6 randomly selected test patients in tenfold cross-validation.
A 100% accurate prediction of an ODI range could be achieved by dividing the ODI scale into 12% sections. A maximum absolute difference of only 3.4% between individually predicted and actual ODI after 6 months of a given therapy was achieved with our most powerful model. The application of artificial intelligence as shown in this work also allowed to compare the actual patient values after 6 months with the prediction for the alternative therapy, showing deviations up to 18.8%.
Deep learning in the supervised form applied here can identify patients at an early stage who would benefit from conservative therapy, and on the contrary avoid painful and unnecessary delays for patients who would profit from surgical therapy. In addition, this approach can be used in many other areas of medicine as an effective tool for decision-making when choosing between opposing treatment options, despite small patient groups.
除了严重神经功能缺损的患者外,对于个体患者,手术治疗与保守治疗腰椎间盘突出症哪一种更优,目前尚不清楚。我们研究了深度学习技术是否可以预测腰椎间盘突出症患者治疗 6 个月后的结局。
使用 60 例患者的数据来训练和测试深度学习算法,目的是准确预测手术或保守治疗后 6 个月的 ODI。我们开发了一种算法,可在十折交叉验证中预测 10 例随机测试患者的 ODI。
将 ODI 量表分为 12%的区间,可实现 100%的 ODI 范围的准确预测。使用我们最强大的模型,治疗 6 个月后,个别预测的 ODI 与实际 ODI 的最大绝对差值仅为 3.4%。正如本工作中所示的人工智能的应用,还可以将治疗 6 个月后的实际患者值与替代治疗的预测值进行比较,显示出高达 18.8%的偏差。
此处应用的有监督深度学习可以在早期识别出从保守治疗中获益的患者,相反,避免对手术治疗有益的患者遭受不必要的疼痛和延误。此外,即使患者人数较少,该方法也可在医学的许多其他领域中作为在相反治疗方案之间进行选择时的有效决策工具。