Klotho 水平降低，并与渗出性年龄相关性黄斑变性患者房水中增强的氧化应激和炎症相关。
Klotho Levels are Decreased and Associated with Enhanced Oxidative Stress and Inflammation in the Aqueous Humor in Patients with Exudative Age-related Macular Degeneration.
机构信息
Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Vision Science, Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China.
Provincial Key Laboratory of Lens Research, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
出版信息
Ocul Immunol Inflamm. 2022 Apr 3;30(3):630-637. doi: 10.1080/09273948.2020.1828488. Epub 2020 Oct 13.
PURPOSE
To evaluate anti-aging protein klotho levels in the aqueous humor and its association with oxidative stress and inflammation in patients with age-related macular degeneration (AMD).
METHODS
Levels of klotho, oxidative, and antioxidative stress markers, and proinflammatory and anti-inflammatory markers in the aqueous humor from 28 patients with exudative AMD and 35 age-matched controls were measured.
RESULTS
Patients with AMD had lower levels of klotho, which were negatively correlated with macular lesion size. Patients with AMD also exhibited increased levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG) and interleukin (IL)-6 but not tumor necrosis factor‑α, and decreased levels of total antioxidant status (TAS) and IL-10. Moreover, levels of klotho were negatively correlated with levels of 8-OHdG and IL-6, but positively correlated with levels of TSA and IL-10.
CONCLUSION
Klotho levels in the aqueous humor are decreased and associated with oxidative stress and inflammation in patients with exudative AMD.
目的
评估与年龄相关的黄斑变性（AMD）患者房水中抗衰老蛋白 klotho 的水平及其与氧化应激和炎症的关系。
方法
测量了 28 名渗出性 AMD 患者和 35 名年龄匹配的对照者房水中 klotho、氧化和抗氧化应激标志物以及促炎和抗炎标志物的水平。
结果
AMD 患者的 klotho 水平较低，与黄斑病变大小呈负相关。AMD 患者还表现出 8-羟基-2'-脱氧鸟苷（8-OHdG）和白细胞介素（IL）-6 水平升高，但肿瘤坏死因子-α水平没有升高，总抗氧化状态（TAS）和 IL-10 水平降低。此外，klotho 水平与 8-OHdG 和 IL-6 水平呈负相关，与 TAS 和 IL-10 水平呈正相关。
结论
渗出性 AMD 患者房水中的 klotho 水平降低，与氧化应激和炎症有关。
Zotero 插件