基于壳聚糖-海藻酸钠的 pH 响应性微凝胶的开发用于模拟体外胃肠道消化条件下包裹胡桃醌。
Development of the pH responsive chitosan-alginate based microgel for encapsulation of Jughans regia L. polyphenols under simulated gastrointestinal digestion in vitro.
机构信息
Hebei Key Laboratory of Applied Chemistry, School of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, 066004, PR China; Hebei Key Laboratory of Heavy Metal Deep-Remediation in Water and Resource Reuse, School of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, 066004, PR China.
Hebei Key Laboratory of Applied Chemistry, School of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, 066004, PR China; Hebei Key Laboratory of Heavy Metal Deep-Remediation in Water and Resource Reuse, School of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, 066004, PR China.
出版信息
Carbohydr Polym. 2020 Dec 15;250:116917. doi: 10.1016/j.carbpol.2020.116917. Epub 2020 Aug 15.
The present research was designed to fabricate a novel pH-responsive microgel based on chitosan/sodium alginate (CS/ALG) to encapsulate the polyphenols from the shells of Juglans regia L. (JRP-Microgel), and investigate the physicochemical properties of JRP-Microgel as well as analyze the release characteristic and phenolic composition variation under simulated gastrointestinal digestion in vitro. The results showed that JRP-Microgel belonged to semi-crystalline substances, and presented regular spherical or subspherical shape with neat edge and uniform particle size. JRP-Microgel possessed better physicochemical stabilities compared with unencapsulated JRP. Furthermore, JRP-Microgel exhibited excellent sustained release characteristic under simulated gastrointestinal digestion. Nevertheless, during different digestive phase, the phenolic composition of microgel was significantly different from the one of untreated JRP, suggesting that JRP-Microgel could prevent the degradation of JRP induced by gastrointestinal digestion. In conclusion, above results provide the experimental basis for the application of microgel encapsulation to improve the bioavailability of phenolic compounds in human body.
本研究旨在制备一种新型的基于壳聚糖/海藻酸钠（CS/ALG）的 pH 响应性微凝胶，用于包封来自核桃壳的多酚（JRP-Microgel），并研究 JRP-Microgel 的理化性质以及分析其在体外模拟胃肠道消化条件下的释放特性和多酚组成变化。结果表明，JRP-Microgel 属于半结晶物质，呈现出规则的球形或类球形，边缘整齐，粒径均匀。与未包封的 JRP 相比，JRP-Microgel 具有更好的物理化学稳定性。此外，JRP-Microgel 在模拟胃肠道消化过程中表现出良好的持续释放特性。然而，在不同的消化阶段，微凝胶的多酚组成与未经处理的 JRP 有显著差异，表明 JRP-Microgel 可以防止胃肠道消化引起的 JRP 降解。综上所述，上述结果为微凝胶包封技术应用于提高人体中酚类化合物的生物利用度提供了实验依据。
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