Tarabeih Nader, Kalinkovich Alexander, Shalata Adel, Livshits Gregory
Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6905126, Israel.
The Simon Winter Institute for Human Genetics, Bnai Zion Medical Center, The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa 32000, Israel.
Diagnostics (Basel). 2020 Oct 8;10(10):797. doi: 10.3390/diagnostics10100797.
Musculoskeletal pain (MSP), specifically low back pain (LBP), is often associated with several adipose tissue-derived cytokines (adipokines) and body composition, but their correlations with the LBP-related disability/severity phenotypes remain poorly understood. In this cross-sectional study, two self-reported validated questionnaires were used to collect back pain and disability data in an ethnically homogeneous family-based population sample ( = 1078). Plasma levels of relatively new adipokines, vaspin and adipsin, were detected by ELISA. Body composition parameters, including fat, skeletal muscle mass, extracellular water (ECW), and others were assessed through bioelectrical impedance analysis (BIA) technology. Statistical analysis was conducted, accounting for the familial composition of the sample. The multiple regression analyses with four LBP-related phenotypes as dependent variables consistently showed, for the first time, the significant associations with vaspin levels, regardless of other covariates. The odds ratios (OR)/SD ranged between 1.24 (95%CI = 1.03-1.50) and 1.33 (95%CI = 1.07-1.64), depending on the LBP phenotype. Among the tested body composition covariates, only ECW levels displayed consistent and highly significant associations with all tested LBP phenotypes (OR from 1.43, 95%CI = 1.14-1.79 to 1.68, 95%CI = 1.26-2.24). The results clearly suggest that circulating concentrations of vaspin and ECW levels could serve as biomarkers of MSP/LBP severity and complications.
肌肉骨骼疼痛（MSP），特别是下背痛（LBP），通常与几种脂肪组织衍生的细胞因子（脂肪因子）和身体组成有关，但其与LBP相关残疾/严重程度表型之间的相关性仍知之甚少。在这项横断面研究中，使用了两份经过验证的自我报告问卷，在一个种族同质的基于家庭的人群样本（n = 1078）中收集背痛和残疾数据。通过酶联免疫吸附测定（ELISA）检测相对较新的脂肪因子——内脏脂肪素和脂肪酶的血浆水平。通过生物电阻抗分析（BIA）技术评估身体组成参数，包括脂肪、骨骼肌质量、细胞外液（ECW）等。进行了统计分析，考虑了样本的家族组成。以四种与LBP相关的表型为因变量的多元回归分析首次一致显示，无论其他协变量如何，均与内脏脂肪素水平存在显著关联。根据LBP表型，优势比（OR）/标准差在1.24（95%CI = 1.03 - 1.50）和1.33（95%CI = 1.07 - 1.64）之间。在测试的身体组成协变量中，只有ECW水平与所有测试的LBP表型均显示出一致且高度显著的关联（OR从1.43，95%CI = 1.14 - 1.79到1.68，95%CI = 1.26 - 2.24）。结果清楚地表明，内脏脂肪素的循环浓度和ECW水平可作为MSP/LBP严重程度和并发症的生物标志物。
