Department of Pediatric Psychiatry, Psychotherapy and Psychosomatics, University of Leipzig, 04107 Leipzig, Germany.
Department of Medicine, Technical University of Dresden, 01309 Dresden, Germany.
Int J Mol Sci. 2020 Oct 9;21(20):7440. doi: 10.3390/ijms21207440.
Variations in anxiety-related behavior are associated with individual allostatic set-points in chronically stressed rats. Actively offensive rats with the externalizing indicators of sniffling and climbing the stimulus and material tearing during 10 days of predator scent stress had reduced plasma corticosterone, increased striatal glutamate metabolites, and increased adrenal 11-dehydrocorticosterone content compared to passively defensive rats with the internalizing indicators of freezing and grooming, as well as to controls without any behavioral changes. These findings suggest that rats that display active offensive activity in response to stress develop anxiety associated with decreased allostatic set-points and increased resistance to stress.
焦虑相关行为的变化与慢性应激大鼠的个体适应设定点有关。在 10 天的捕食者气味应激期间，具有外部表现（如嗅探和攀爬刺激物）和物质撕裂行为的主动攻击型大鼠的血浆皮质酮水平降低，纹状体谷氨酸代谢物增加，肾上腺 11-去氢皮质酮含量增加，而表现出内化表现（如冻结和梳理）的被动防御型大鼠以及没有任何行为变化的对照组大鼠则相反。这些发现表明，对压力做出主动攻击反应的大鼠表现出与适应设定点降低和对压力抵抗力增强相关的焦虑。
