Makri Olga E, Pallikari Athina, Kagkelaris Konstantinos, Mastronikolis Stylianos N, Karanasios Georgios, Symeonidis Chrysanthos, Plotas Panagiotis, Georgakopoulos Constantine D
Department of Ophthalmology, Medical School, University of Patras, 26504 Patras, Greece.
Department of Pharmacy, Medical School, University of Patras, 26504 Patras, Greece.
Toxics. 2020 Oct 11;8(4):85. doi: 10.3390/toxics8040085.
The present study aims to evaluate and compare the acute effects of tobacco cigarettes (TC) smoking and electronic cigarette (EC) vaping on foveal and choroidal thickness (CT) in young, healthy, dual smokers. Participants underwent four trials: 5 min TC; 5 min EC; 30 min EC; and 60 min nothing (sham trial). Scans before and immediately after each trial were obtained using spectral domain optical coherence tomography with the enhanced depth imaging mode. Changes in central foveal thickness (CFT), subfoveal choroidal thickness (SFCT), and CT at fourother points, 500 μm and 1000 μm temporally and nasally to the fovea, were measured. Forty-seven participants (33 male, 14 female; mean age 24.85 ± 1.57 years) were included. They smoked 13.53 ± 5.27 TCs/day for 6 ± 2.3 years and vaped ECs for the past 2.4 ± 1.08 years. We did not observe any statistically significant change in SFCT, CFT, and CT of the other points after any of the fourtrials. The acute changes in CFT and CT after EC vaping or TC smoking did not differ significantly compared to the sham trial. Smoking and vaping does not seem to result in statistically significant acute alterations in foveal and CT in young, dual smokers.
本研究旨在评估和比较吸烟与吸电子烟对年轻、健康的双重吸烟者中央凹和脉络膜厚度（CT）的急性影响。参与者接受了四项试验：5分钟吸烟；5分钟吸电子烟；30分钟吸电子烟；以及60分钟无干预（假试验）。在每次试验前和试验后立即使用增强深度成像模式的光谱域光学相干断层扫描进行扫描。测量中央凹厚度（CFT）、中央凹下脉络膜厚度（SFCT）以及在中央凹颞侧和鼻侧500μm和1000μm处的其他四个点的脉络膜厚度变化。纳入了47名参与者（33名男性，14名女性；平均年龄24.85±1.57岁）。他们每天吸13.53±5.27支香烟，持续6±2.3年，并且在过去2.4±1.08年里吸电子烟。在四项试验中的任何一项之后，我们均未观察到SFCT、CFT以及其他点的脉络膜厚度有任何统计学上的显著变化。与假试验相比，吸电子烟或吸烟后CFT和脉络膜厚度的急性变化无显著差异。吸烟和吸电子烟似乎不会导致年轻双重吸烟者的中央凹和脉络膜厚度出现统计学上的显著急性改变。
