Assistant professor, Microbiology and Immunology Department, Faculty of Pharmacy, Deraya University, Minia, Egypt.
Professor, Microbiology and Immunology Department, Faculty of Pharmacy, Minia University, Minia, Egypt.
Trop Doct. 2021 Jan;51(1):40-44. doi: 10.1177/0049475520962740. Epub 2020 Oct 13.
Coagulase-negative staphylococci (CoNS) are frequently isolated from wound infections. There are limited data examining the prevalence of methicillin-resistant CoNS (MRCoNS) among Egyptian patients after surgery. Thus, we studied 208 hospitalised patients, who had skin and soft tissue infections (SSTIs) due to various causes. Samples were cultured for isolation and identification of CoNS and isolates were screened for susceptibility against 23 different antimicrobials. Out of 241 Staphylococcal isolates, 114 (47.3%) were CoNS. The prevalence of MRCoNS among surgical site infection, diabetic foot, abscess, and burn patients was 13.4%, 11.5%, 15.6%, and 10.3%, respectively. The lowest resistance of the 27 identified MRCoNS isolates was to vancomycin, amikacin and gatifloxacin (7% each). We conclude that CoNS isolates are major pathogens associated with wound infections at our institution and MRCoNS probably poses a substantial threat for patients in Egypt, though most MRCoNS isolates demonstrated susceptibility to vancomycin.
凝固酶阴性葡萄球菌（CoNS）经常从伤口感染中分离出来。关于埃及手术后耐甲氧西林凝固酶阴性葡萄球菌（MRCoNS）的流行率，相关数据有限。因此，我们研究了 208 名患有各种原因导致的皮肤和软组织感染（SSTIs）的住院患者。对这些患者的样本进行培养，以分离和鉴定 CoNS，并对分离物进行了 23 种不同抗菌药物敏感性的筛查。在 241 株葡萄球菌分离株中，有 114 株（47.3%）为 CoNS。手术部位感染、糖尿病足、脓肿和烧伤患者的 MRCoNS 患病率分别为 13.4%、11.5%、15.6%和 10.3%。27 株鉴定出的 MRCoNS 分离株对万古霉素、阿米卡星和加替沙星的耐药率最低（分别为 7%）。我们得出结论，CoNS 分离株是我们机构与伤口感染相关的主要病原体，MRCoNS 可能对埃及的患者构成重大威胁，尽管大多数 MRCoNS 分离株对万古霉素敏感。
