Suster S, Huszar M, Herczeg E
Histopathology. 1987 Aug;11(8):871-8. doi: 10.1111/j.1365-2559.1987.tb01890.x.
A case of squamous cell carcinoma of the lung showing extensive spindle transformation is presented. On light microscopy, the tumour showed sheets and fascicles of elongated fusiform cells resulting in a growth pattern which closely resembled a sarcoma. Immunocytochemistry using tissue-specific antibodies against intermediate filaments demonstrated exclusive labelling of the tumour cells with prekeratin antibodies. Electron microscopy showed well-formed intercellular junctions and thick bundles of tonofilaments within the cytoplasm of the cells further confirming the squamous epithelial nature of the neoplasm. The findings in the present case point to the existence of a non-metaplastic spindle cell variant of squamous carcinoma of the lung. The possible mechanisms which may account for the spindle shape of the cells are reviewed.
本文报告一例肺鳞状细胞癌呈现广泛梭形转化的病例。在光学显微镜下，肿瘤表现为细长梭形细胞的片状和束状结构，形成的生长模式与肉瘤极为相似。使用针对中间丝的组织特异性抗体进行免疫细胞化学检测显示，肿瘤细胞仅被前角蛋白抗体标记。电子显微镜显示细胞间有良好形成的连接，细胞胞质内有粗大的张力丝束，进一步证实了该肿瘤的鳞状上皮性质。本病例的发现表明存在一种非化生的肺鳞状细胞癌梭形细胞变体。文中还对可能导致细胞呈梭形的机制进行了综述。
