来自星形诺卡氏菌GUH-2的2,3-二羟基苯甲酸的特性分析。
Characterization of 2,3-dihydroxybenzoic acid from Nocardia asteroides GUH-2.
作者信息
Feistner G J, Beaman B L
出版信息
J Bacteriol. 1987 Sep;169(9):3982-7. doi: 10.1128/jb.169.9.3982-3987.1987.
Abstract
Culture filtrates of virulent Nocardia asteroides GUH-2 after growth in acetate minimal medium displayed an absorbance maximum at 320 nm. After isolation by polyamide extraction and anion chromatography, a UV-active compound with this absorbance was shown to be 2,3-dihydroxybenzoic acid (DHB) by nuclear magnetic resonance, gas chromatographic, and mass spectrometric techniques. DHB production under several culture conditions was quantified by a standard high-pressure liquid chromatography assay. Under iron deficiency conditions, N. asteroides GUH-2 excreted up to 11 mg of DHB per liter into the culture medium. No DHB was detected when N. asteroides GUH-2 was grown in an iron-rich medium. With the less virulent strain N. asteroides 10905, DHB was not found under any condition tested.
摘要
强毒星形诺卡菌GUH-2在乙酸盐基本培养基中生长后的培养滤液在320nm处有最大吸光度。通过聚酰胺萃取和阴离子色谱分离后，利用核磁共振、气相色谱和质谱技术表明，具有该吸光度的紫外线活性化合物为2,3-二羟基苯甲酸（DHB）。通过标准的高压液相色谱分析对几种培养条件下的DHB产量进行了定量。在缺铁条件下，星形诺卡菌GUH-2每升培养基中可分泌高达11mg的DHB。当星形诺卡菌GUH-2在富铁培养基中生长时，未检测到DHB。对于毒力较弱的菌株星形诺卡菌10905，在任何测试条件下均未发现DHB。
相似文献
1
Characterization of 2,3-dihydroxybenzoic acid from Nocardia asteroides GUH-2.来自星形诺卡氏菌GUH-2的2,3-二羟基苯甲酸的特性分析。
J Bacteriol. 1987 Sep;169(9):3982-7. doi: 10.1128/jb.169.9.3982-3987.1987.
2
Role of superoxide dismutase and catalase as determinants of pathogenicity of Nocardia asteroides: importance in resistance to microbicidal activities of human polymorphonuclear neutrophils.超氧化物歧化酶和过氧化氢酶作为星状诺卡菌致病性决定因素的作用：在抵抗人多形核中性粒细胞杀菌活性中的重要性。
Infect Immun. 1985 Jan;47(1):135-41. doi: 10.1128/iai.47.1.135-141.1985.
3
Characterization of dopamine-depleting activity of Nocardia asteroides strain GUH-2 culture filtrate on PC12 cells.诺卡氏菌属星状菌株GUH-2培养滤液对PC12细胞的多巴胺消耗活性的表征
Microb Pathog. 2004 Aug;37(2):73-85. doi: 10.1016/j.micpath.2004.05.001.
4
Composition and toxicity of diethyl ether soluble lipids from Nocardia asteroides GUH-2 and Nocardia asteroides 10905.
Chem Phys Lipids. 1993 Oct;65(3):171-8. doi: 10.1016/0009-3084(93)90015-u.
5
Pathogenic and virulence characterization of colonial mutants of Nocardia asteroides GUH-2.
Can J Microbiol. 1983 Sep;29(9):1126-35. doi: 10.1139/m83-173.
6
Acid-fastness of Nocardia asteroides GUH-2 cultured in brain heart infusion broth supplemented with paraffin.在补充石蜡的脑心浸液肉汤中培养的星形诺卡菌GUH-2的抗酸性。
Microbiol Immunol. 1996;40(10):711-6. doi: 10.1111/j.1348-0421.1996.tb01131.x.
7
Influence of cultural conditions on growth and lipolytic activity in Nocardia asteroides.培养条件对星形诺卡氏菌生长及脂解活性的影响
Folia Microbiol (Praha). 1993;38(6):451-5. doi: 10.1007/BF02814394.
8
Effect of growth stage on mycolic acid structure in cell walls of Nocardia asteroides GUH-2.生长阶段对星形诺卡氏菌GUH-2细胞壁中分枝菌酸结构的影响。
J Bacteriol. 1988 Mar;170(3):1137-42. doi: 10.1128/jb.170.3.1137-1142.1988.
9
Effect of cyclophosphamide on experimental Nocardia asteroides infection in mice.
Infect Immun. 1977 Jun;16(3):995-1004. doi: 10.1128/iai.16.3.995-1004.1977.
10
Interaction of Nocardia asteroides with rabbit alveolar macrophages: association of virulence, viability, ultrastructural damage, and phagosome-lysosome fusion.星形诺卡菌与兔肺泡巨噬细胞的相互作用：毒力、活力、超微结构损伤及吞噬体-溶酶体融合的关联
Infect Immun. 1980 May;28(2):610-9. doi: 10.1128/iai.28.2.610-619.1980.
引用本文的文献
1
Isolation of Petrocidin A, a New Cytotoxic Cyclic Dipeptide from the Marine Sponge-Derived Bacterium Streptomyces sp. SBT348.从海洋海绵来源的链霉菌属 SBT348 中分离得到新的细胞毒性环二肽 Petrocidin A。
Mar Drugs. 2017 Dec 6;15(12):383. doi: 10.3390/md15120383.
2
Isolation and structure elucidation of acinetobactin, a novel siderophore from Acinetobacter baumannii.鲍曼不动杆菌新型铁载体鲍曼不动菌素的分离与结构解析
Arch Microbiol. 1994;162(4):249-54. doi: 10.1007/BF00301846.
3
Use of a siderophore detection medium, ethylene glycol degradation, and beta-galactosidase activity in the early presumptive differentiation of Nocardia, Rhodococcus, Streptomyces, and rapidly growing Mycobacterium species.利用铁载体检测培养基、乙二醇降解及β-半乳糖苷酶活性对诺卡氏菌、红球菌、链霉菌和快速生长的分枝杆菌属进行早期初步鉴别
J Clin Microbiol. 1991 Jul;29(7):1533-5. doi: 10.1128/jcm.29.7.1533-1535.1991.
4
Identification of 2,3-dihydroxybenzoic acid as a Brucella abortus siderophore.鉴定2,3 - 二羟基苯甲酸为流产布鲁氏菌的铁载体。
Infect Immun. 1992 Nov;60(11):4496-503. doi: 10.1128/iai.60.11.4496-4503.1992.
本文引用的文献
1
Siderochelin, a new ferrous-ion chelating agent produced by Nocardia.
J Antibiot (Tokyo). 1981 Jul;34(7):791-9. doi: 10.7164/antibiotics.34.791.
2
Nocardial infections in the immunocompromised host: A detailed study in a defined population.免疫功能低下宿主中的诺卡菌感染：对特定人群的详细研究。
Rev Infect Dis. 1981 May-Jun;3(3):492-507. doi: 10.1093/clinids/3.3.492.
3
Interaction of Nocardia asteroides with rabbit alveolar macrophages: effect of growth phase and viability on phagosome-lysosome fusion.星形诺卡菌与兔肺泡巨噬细胞的相互作用：生长阶段和活力对吞噬体-溶酶体融合的影响。
Infect Immun. 1980 Jul;29(1):24-9. doi: 10.1128/iai.29.1.24-29.1980.
4
Interaction of Nocardia asteroides with rabbit alveolar macrophages: association of virulence, viability, ultrastructural damage, and phagosome-lysosome fusion.星形诺卡菌与兔肺泡巨噬细胞的相互作用：毒力、活力、超微结构损伤及吞噬体-溶酶体融合的关联
Infect Immun. 1980 May;28(2):610-9. doi: 10.1128/iai.28.2.610-619.1980.
5
Relationship of siderophore-mediated iron assimilation to virulence in crown gall disease.铁载体介导的铁同化与冠瘿病致病性的关系。
J Bacteriol. 1981 Aug;147(2):482-91. doi: 10.1128/jb.147.2.482-491.1981.
6
The role of oxygen and its derivatives in microbial pathogenesis and host defense.氧气及其衍生物在微生物致病机制和宿主防御中的作用。
Annu Rev Microbiol. 1984;38:27-48. doi: 10.1146/annurev.mi.38.100184.000331.
7
Resistance of Nocardia asteroides to oxygen-dependent killing by neutrophils.
J Infect Dis. 1983 Nov;148(5):861-7. doi: 10.1093/infdis/148.5.861.
8
Siderophores of bacteria and fungi.细菌和真菌的铁载体
Microbiol Sci. 1984 Apr;1(1):9-14.
9
Siderophore production by phytopathogenic microbial species.植物病原微生物物种产生铁载体的情况。
Arch Biochem Biophys. 1982 Oct 15;218(2):351-9. doi: 10.1016/0003-9861(82)90356-3.
10
The isolation and identification of 2,3-dihydroxybenzoic acid and 2-N,6-N-di-92,3-dihydroxybenzoyl)-L-lysine formed by iron-deficient Azotobacter vinelandii.由缺铁的棕色固氮菌形成的2,3 - 二羟基苯甲酸和2 - N,6 - N - 二 -（2,3 - 二羟基苯甲酰基）- L - 赖氨酸的分离与鉴定
Biochemistry. 1969 Mar;8(3):757-62. doi: 10.1021/bi00831a002.
Zotero 插件