Yamamoto S, Okujo N, Sakakibara Y
Faculty of Pharmaceutical Sciences, Okayama University, Japan.
Arch Microbiol. 1994;162(4):249-54. doi: 10.1007/BF00301846.
A novel siderophore, called acinetobactin, with both catecholate and hydroxamate functional groups was isolated from low-iron cultures of Acinetobacter baumannii ATCC 19606. The structure was elucidated by chemical degradation, fast-atom bombardment mass spectrometry and 1H and 13C NMR spectroscopy. Acinetobactin was composed of omega-N-hydroxyhistamine, threonine and 2,3-dihydroxybenzoic acid, the last two components forming an oxazoline ring. Acinetobactin was structurally related to anguibactin, a plasmid-encoded siderophore of Vibrio anguillarum. The only difference was that acinetobactin possessed an oxazoline ring instead of a thiazoline ring. Four of 12 other clinical A. baumannii strains examined produced acinetobactin, indicative of strain-to-strain variation in the ability to produce acinetobactin. In addition, a relatively small amount of acinetobactin was also detected in A. haemolyticus ATCC 17906.
从鲍曼不动杆菌ATCC 19606的低铁培养基中分离出一种新型铁载体，称为不动杆菌铁载体，它同时含有儿茶酚和异羟肟酸官能团。通过化学降解、快原子轰击质谱以及1H和13C核磁共振光谱对其结构进行了阐明。不动杆菌铁载体由ω-N-羟基组胺、苏氨酸和2,3-二羟基苯甲酸组成，后两种成分形成一个恶唑啉环。不动杆菌铁载体在结构上与鳗弧菌质粒编码的铁载体鳗弧菌素相关。唯一的区别是不动杆菌铁载体含有一个恶唑啉环而非噻唑啉环。在所检测的其他12株临床鲍曼不动杆菌菌株中，有4株产生不动杆菌铁载体，这表明不同菌株产生不动杆菌铁载体的能力存在差异。此外，在溶血不动杆菌ATCC 17906中也检测到了相对少量的不动杆菌铁载体。
