Jarry A, Brousse N, Souque A, Barge J, Molas G, Potet F
J Clin Pathol. 1987 Jul;40(7):760-5. doi: 10.1136/jcp.40.7.760.
The lymphoid stromal reaction, particularly the T lymphoid reaction, was studied immunohistochemically on cryostat sections in 14 cases of primary gastrointestinal B lymphomas, and compared with the type and distribution of lymphoid cells in three cases of gastric lymphoid hyperplasia. A pronounced T lymphoid reaction, mainly of the T helper phenotype, occurred in both lesions. Most of these T cells bore HLA-DR antigens, but only a few of them had the receptor for interleukin 2. The T lymphoid reaction was observed inside the lymphomas in seven of a total of 14 cases, and around the lymphomas in four of the six cases clinically classified as stage I. Perivascular mucosal and submucosal nodules, entirely composed of T cells, seemed characteristic of gastric lymphoid hyperplasias. A T lymphoid reaction in lymphoid hyperplasias suggests an amplification of the cell mediated immune response; in lymphomas it could represent a host reaction against the lymphomatous infiltrate, therefore favouring a better prognosis.
对14例原发性胃肠道B淋巴瘤的冷冻切片进行免疫组织化学研究，观察其淋巴样间质反应，尤其是T淋巴细胞反应，并与3例胃淋巴样增生的淋巴细胞类型和分布进行比较。在这两种病变中均出现明显的T淋巴细胞反应，主要为T辅助细胞表型。这些T细胞大多数表达HLA-DR抗原，但只有少数细胞具有白细胞介素2受体。在总共14例病例中，有7例在淋巴瘤内部观察到T淋巴细胞反应，在临床分类为I期的6例病例中，有4例在淋巴瘤周围观察到T淋巴细胞反应。完全由T细胞组成的血管周围黏膜和黏膜下结节似乎是胃淋巴样增生的特征。淋巴样增生中的T淋巴细胞反应提示细胞介导的免疫反应增强；在淋巴瘤中，它可能代表宿主对淋巴瘤浸润的反应，因此预后较好。
