Medical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK.
J Cell Biol. 2020 Nov 2;219(11). doi: 10.1083/jcb.202009040.
In the Drosophila larval optic lobe, the generation of neural stem cells involves an epithelial-to-mesenchymal-like transition of a continuous stripe of cells that sweeps across the neuroepithelium, but the dynamics at cell and tissue level were unknown until now. In this issue, Shard et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.202005035) identify that Neuralized controls a partial epithelial-to-mesenchymal transition through regulation of the apical Crumbs complex and through the coordination of cell behaviors such as apical constriction and cell alignment.
在果蝇幼虫的颅神经节中，神经干细胞的产生涉及到细胞的上皮-间质样转变，这个过程发生在横跨神经上皮的连续细胞带上，但直到现在，细胞和组织层面的动态变化还不清楚。在本期杂志中，Shard 等人（2020. J. Cell Biol. https://doi.org/10.1083/jcb.202005035）发现 Neuralized 通过调节顶端的 Crumbs 复合物，以及协调细胞行为，如顶端缢缩和细胞对齐，来控制部分上皮-间质样转变。
