Sidor Clara, Röper Katja
Medical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge CB2 0QH, England, UK
J Cell Biol. 2017 May 1;216(5):1215-1218. doi: 10.1083/jcb.201702116. Epub 2017 Apr 12.
Neural stem cells or neuroblasts in the embryo delaminate as single cells from the embryonic epidermis to give rise to the nervous system. Using this accessible system to examine the molecular mechanisms of cell ingression at a high temporal and spatial resolution, in this issue, Simões et al. (2017. https://doi.org/10.1083/jcb.201608038) reveal that myosin-driven anisotropic junction loss and apical constriction are the main drivers of this process.
胚胎中的神经干细胞或神经母细胞作为单个细胞从胚胎表皮脱层，从而产生神经系统。利用这个易于研究的系统，以高时空分辨率研究细胞内陷的分子机制，在本期中，西芒斯等人（2017年。https://doi.org/10.1083/jcb.201608038）揭示，肌球蛋白驱动的各向异性连接丧失和顶端收缩是这一过程的主要驱动力。
