Röper Katja
MRC-Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK.
Bioarchitecture. 2013 Mar-Apr;3(2):45-9. doi: 10.4161/bioa.25339. Epub 2013 Mar 1.
Changes in cell shape are one of the driving forces of tissue morphogenesis. Contractile cytoskeletal assemblies based on actomyosin networks have emerged as a main player that can drive these changes. Different types of actomyosin networks have been identified, with distinct subcellular localizations, including apical junctional and apicomedial actomyosin. A further specialization of junctional actomyosin are so-called actomyosin 'cables', supracellular arrangements that appear to stretch over many cell diameters. Such actomyosin cables have been shown to serve several important functions, in processes such as wound healing, epithelial morphogenesis and maintenance of compartment identities during development. In the Drosophila embryo, we have recently identified a function for a circumferential actomyosin cable in assisting tube formation. Here, I will briefly summarize general principles that have emerged from the analysis of such cables.
细胞形状的变化是组织形态发生的驱动力之一。基于肌动球蛋白网络的收缩性细胞骨架组装体已成为驱动这些变化的主要因素。已鉴定出不同类型的肌动球蛋白网络，它们具有不同的亚细胞定位，包括顶端连接和顶内侧肌动球蛋白。连接肌动球蛋白的进一步特化是所谓的肌动球蛋白“束”，即超细胞排列，似乎能延伸多个细胞直径。已证明这种肌动球蛋白束在伤口愈合、上皮形态发生和发育过程中隔室身份的维持等过程中发挥多种重要功能。在果蝇胚胎中，我们最近发现了一种周向肌动球蛋白束在协助管道形成中的功能。在此，我将简要总结从对这些束的分析中得出的一般原理。
