Department of Dermatology, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Department of Microbiology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China.
J Med Virol. 2021 Jun;93(6):4038-4041. doi: 10.1002/jmv.26603. Epub 2020 Oct 30.
Here, using viral metagenomics, a novel anellovirus with strain name HuAV-zj-ad1 was detected in blood sample from a child with atopic dermatitis. The complete genome sequence of HuAV-zj-ad1 was determined and fully characterized. The circular genome of HuAV-zj-ad1 is 2841 nt in length and includes four polyprotein ORFs. Phylogenetic analysis and pairwise sequence comparisons based on the amino acid sequences of ORF1, ORF2, ORF3, ORF4 indicated that HuAV-zj-ad1 belonged to a novel species within the genus Betatorquevirus. Polymerase chain reaction screening results showed this anellovirus was not present 50 blood samples from normal children. Whether this novel species of anellovirus has association with a certain disease needs further study.
在这里，使用病毒宏基因组学，在一名特应性皮炎患儿的血液样本中检测到一种新型环状病毒，命名为 HuAV-zj-ad1。确定并充分表征了 HuAV-zj-ad1 的完整基因组序列。HuAV-zj-ad1 的圆形基因组长 2841nt，包含四个多蛋白 ORF。基于 ORF1、ORF2、ORF3 和 ORF4 的氨基酸序列进行的系统进化分析和两两序列比较表明，HuAV-zj-ad1 属于贝塔托奎病毒属中的一个新型种。聚合酶链反应筛选结果显示，该环状病毒不存在于 50 份正常儿童的血液样本中。这种新型环状病毒是否与某种疾病有关，需要进一步研究。
