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亚甲蓝光动力疗法治疗铜绿假单胞菌和镰刀菌属感染的皮肤溃疡

Photodynamic Therapy With Methylene Blue for Skin Ulcers Infected With Pseudomonas aeruginosa and Fusarium spp.

作者信息

Aspiroz C, Sevil M, Toyas C, Gilaberte Y

机构信息

Sección de Microbiología, Hospital Royo Villanova, Zaragoza, España.

Servicio de Medicina Interna, Hospital Royo Villanova, Zaragoza, España.

出版信息

Actas Dermosifiliogr. 2017 Jul-Aug;108(6):e45-e48. doi: 10.1016/j.ad.2016.11.020. Epub 2017 Apr 13.

DOI:10.1016/j.ad.2016.11.020
PMID:28411862
Abstract

Photodynamic therapy (PDT) is a therapeutic modality with significant antimicrobial activity. We present 2 cases of chronic lower limb ulcers in which fungal and bacterial superinfection complicated management. PDT with methylene blue as the photosensitizer led to clinical and microbiological cure with no significant adverse effects. PDT with methylene blue is a valid option for the management of superinfected chronic ulcers, reducing the use of antibiotics and the induction of resistance.

摘要

光动力疗法（PDT）是一种具有显著抗菌活性的治疗方式。我们报告2例慢性下肢溃疡病例，其中真菌和细菌的二重感染使治疗变得复杂。以亚甲蓝作为光敏剂的光动力疗法实现了临床和微生物学治愈，且无明显不良反应。以亚甲蓝进行光动力疗法是治疗二重感染慢性溃疡的有效选择，可减少抗生素的使用及耐药性的产生。

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