Department of Emergency Medicine, State University of New York at Buffalo, Buffalo, NY, United States of America.
Department of Emergency Medicine, Grand Strand Medical Center, University of South Carolina, Myrtle Beach, SC, United States of America.
Am J Emerg Med. 2021 Jul;45:317-323. doi: 10.1016/j.ajem.2020.08.081. Epub 2020 Sep 4.
To determine whether the combination of skin tapes and tissue adhesive is superior to either method alone for laceration repair.
This was a prospective, longitudinal experiment on six anesthetized swine. Thirty-six full-thickness linear wounds were created using a metal template, then closed using one of three methods: skin tapes over benzoin, tissue adhesive, or a combination of both. The study was done in two parts. Group 1 (immediate excision) animals were euthanized at day zero for skin excision and tensile strength testing following wound repair. Group 2 (delayed excision) had initial wound repair; animals were euthanized at day 35 for skin excision and tensile strength testing.
In Group 1, the combination of skin tapes and tissue adhesive provided the strongest immediate wound closure. Average mean force for disruption immediately after wound repair was 19.9 lbs. for the tapes and tissue adhesive group compared to 9.6 lbs. for adhesive alone and 8.9 lbs. for tapes alone. The difference in mean force for combination repair vs. tapes alone was 10.3 lbs. (95% CI 4.1, 16.7), and combination vs. adhesive alone was 10.9 lbs. (95% CI 4.7, 17.3). In Group 2, the mean force required for laceration disruption for those repaired with both tape and tissue adhesive was 188.9 lbs. The mean force until wound disruption for tape only was 165.6 lbs., and the mean force until wound disruption for tissue adhesive alone was 118.9 lbs. The difference in mean force required for wound disruption for those repaired with adhesive alone vs. combination repair is 66.5 lbs. (95% CI 21.2, 111.9). The difference in mean force required for wound disruption between the other two groups was not statistically significant.
This study demonstrates that the combination of skin tapes and tissue adhesive provides superior immediate wound closure strength to either of these methods alone in a porcine model.
确定皮肤胶带和组织粘合剂的联合使用是否优于单独使用这两种方法用于伤口修复。
这是一项对六头麻醉猪进行的前瞻性、纵向实验。使用金属模板创建 36 个全层线性伤口，然后使用以下三种方法之一进行闭合：苯佐卡因上的皮肤胶带、组织粘合剂或两者的组合。该研究分为两部分。第 1 组（即刻切除）动物在伤口修复后第 0 天进行皮肤切除和拉伸强度测试，然后安乐死。第 2 组（延迟切除）进行初始伤口修复；第 35 天动物进行皮肤切除和拉伸强度测试，然后安乐死。
在第 1 组中，皮肤胶带和组织粘合剂的联合使用提供了最强的即时伤口闭合。伤口修复后立即破坏的平均平均力为胶带和组织粘合剂组 19.9 磅，而单独使用粘合剂的平均力为 9.6 磅，单独使用胶带的平均力为 8.9 磅。组合修复与单独使用胶带的平均力差异为 10.3 磅（95%CI 4.1,16.7），与单独使用粘合剂的差异为 10.9 磅（95%CI 4.7,17.3）。在第 2 组中，用胶带和组织粘合剂修复的伤口撕裂所需的平均力为 188.9 磅。仅用胶带的平均撕裂力为 165.6 磅，单独使用组织粘合剂的平均撕裂力为 118.9 磅。单独使用粘合剂修复与组合修复的伤口撕裂所需平均力的差异为 66.5 磅（95%CI 21.2,111.9）。其他两组之间的平均撕裂力差异无统计学意义。
本研究表明，在猪模型中，皮肤胶带和组织粘合剂的联合使用比单独使用这两种方法提供了更强的即时伤口闭合强度。
