Department of Dermatology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.
Institute of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China.
Sci Rep. 2020 Oct 15;10(1):17400. doi: 10.1038/s41598-020-74501-2.
Smoking has been identified as a risk factor for atopic dermatitis and hand eczema, but less is known about the association of exposure to second-hand smoke (SHS) with hand eczema. The study aimed to investigate the association of SHS exposure with hand eczema and atopic dermatitis in a group of adolescents. We conducted a cross-sectional study among first-year college students. SHS exposure was measured by a self-administered questionnaire. Skin diseases were diagnosed by dermatologists in the field survey. Mixed models were used to estimate the associations. A total of 20,129 participants that underwent skin examination and a questionnaire survey were included in the analyses. The prevalence rates of atopic dermatitis and hand eczema were 3.86% and 3.35%, respectively. Crude and adjusted estimates consistently showed that exposure to SHS was significantly associated with atopic dermatitis and hand eczema in a dose-response manner. Attention deficit/hyperactivity disorder mediated minimal or no effect of SHS on hand eczema and atopic dermatitis. Subgroup analysis by type of hand eczema, and sensitivity analysis by excluding data with center effect showed consistent results. Exposure to SHS is an independent but modifiable risk factor for hand eczema and atopic dermatitis in adolescents.
吸烟已被确定为特应性皮炎和手部湿疹的危险因素，但对于二手烟（SHS）暴露与手部湿疹之间的关联知之甚少。本研究旨在调查 SHS 暴露与一组青少年手部湿疹和特应性皮炎之间的关联。我们在大一学生中进行了一项横断面研究。通过自我管理问卷测量 SHS 暴露。皮肤病由现场调查的皮肤科医生诊断。混合模型用于估计关联。共纳入 20129 名接受皮肤检查和问卷调查的参与者进行分析。特应性皮炎和手部湿疹的患病率分别为 3.86%和 3.35%。未调整和调整后的估计值均表明，SHS 暴露与特应性皮炎和手部湿疹之间存在剂量反应关系。注意缺陷/多动障碍对 SHS 对手部湿疹和特应性皮炎的影响最小或没有影响。根据手部湿疹的类型进行亚组分析，并排除具有中心效应的数据进行敏感性分析，结果一致。暴露于 SHS 是青少年手部湿疹和特应性皮炎的一个独立但可改变的危险因素。
