Department of Biostatistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
School of Psychology and Counselling, Queensland University of Technology, Brisbane, QLD, Australia.
Environ Res. 2019 Oct;177:108612. doi: 10.1016/j.envres.2019.108612. Epub 2019 Jul 26.
Prenatal exposure to air pollutants has been suggested as a possible etiologic factor for the occurrence of ADHD or ADHD-like behaviors. But we still lack a comprehensive assessment of household air pollutants exposure on the development of ADHD-like behaviors during childhood.
We aimed to assess whether prenatal household inhalants exposure is associated with preschoolers' ADHD-like behaviors in a nonclinical population.
This study used the baseline data of the Longhua Child Cohort Study. During 2015-2017, we recruited 42,983 mothers and their kindergarten-aged children who enrolled at kindergarten in the Longhua district of Shenzhen, to obtain the demographic data and relevant exposure information through self-administrated questionnaire survey. The source of prenatal household inhalants exposure include cooking fumes, environmental tobacco smoke, mosqutio coils, home renovated and indoor burning incense. Logistic and censored least absolute deviations (CLAD) models were used to reveal the association between prenatal exposure to household air pollutants and hyperactive behaviors in child.
We found that exposure to five types of household inhalants during pregnancy were independently associated with an increased risk of child hyperactive behaviors. Moreover, we observed a significant interaction between exposure to environmental tobacco smoke and cooking fumes during gestation on child hyperactive behaviors in CLAD models. We also found a significant joint effect between burning mosquito coils and incense during gestation for child hyperactive behaviors risk both in CLAD and Logistic models. Furthermore, a household inhalants exposure index was used to demonstrate a dose-response relationship between the cumulative effect of exposure to the five household air pollutants and child hyperactivity.
Our results suggest that prenatal exposure to different household inhalants might increase the risk of children's hyperactive behaviors at around 3 years of age with the presence of interaction effects between some inhalants.
有研究提示，产前暴露于空气污染物可能是 ADHD 或类似 ADHD 行为发生的一个病因因素。但我们仍缺乏全面评估家庭空气污染物暴露对儿童时期发生类似 ADHD 行为的影响。
我们旨在评估在非临床人群中，产前家庭吸入剂暴露是否与学龄前儿童类似 ADHD 行为有关。
本研究使用了龙华儿童队列研究的基线数据。在 2015-2017 年期间，我们招募了 42983 名母亲及其幼儿园年龄的儿童，他们在深圳市龙华区的幼儿园入学，通过自填式问卷调查获得人口统计学数据和相关暴露信息。产前家庭吸入剂暴露的来源包括烹饪油烟、环境烟草烟雾、蚊香、家庭装修和室内焚香。我们采用逻辑回归和有条件最小绝对偏差（CLAD）模型来揭示产前暴露于家庭空气污染物与儿童多动行为之间的关联。
我们发现，妊娠期间暴露于五种类型的家庭吸入剂与儿童多动行为的风险增加独立相关。此外，我们在 CLAD 模型中观察到妊娠期间暴露于环境烟草烟雾和烹饪油烟之间存在显著的交互作用。我们还发现，妊娠期间燃烧蚊香和焚香之间存在显著的联合效应，对儿童多动行为风险的影响在 CLAD 和逻辑回归模型中均存在。此外，我们还使用家庭吸入剂暴露指数来显示五种家庭空气污染物暴露的累积效应与儿童多动之间的剂量-反应关系。
我们的研究结果表明，产前暴露于不同的家庭吸入剂可能会增加儿童约 3 岁时多动行为的风险，且一些吸入剂之间存在交互作用。
