BACKGROUND AND AIM

The presence of gastric mucosa or submucosa inflammation due to leads to histological changes. Gastric injury, pro-inflammatory factors, and oxidative stress in infection produce asymmetric dimethylarginine (ADMA), which are a competitive inhibitor of nitric oxide synthase. Investigations were carried out aimed at finding new drugs derived from natural products for the treatment of . is known to have anti-inflammatory and antimicrobial properties. This study aimed to investigate the effect of extract and a standard eradication regimen on ADMA levels and histological changes in the gastritis rat model.

MATERIALS AND METHODS

Thirty-five male rats were randomly and equally divided into five groups. Group-1 was the negative control group and Groups-2 to 5 were -infected groups. Groups-3 to 5 were administered extract, a standard eradication regimen, and a combination of standard eradication regimen and extract, respectively. Histological examination and serum ADMA levels were analyzed. The difference between groups was analyzed using the Kruskal-Wallis and one-way analysis of variance tests. The significance was p<0.05.

RESULTS

Serum ADMA levels and severity of gastritis were higher in infected groups compared to the negative control group (p<0.05). The severity of gastritis and mean ADMA levels in the group that received a single administration of the extract was higher than the others (p<0.05). Serum ADMA levels and severity of gastritis were significantly reduced in the group that received a combination of standard eradication regimen and extract (p<0.05).

CONCLUSION

Single administration of extract worsens the severity of gastritis and increased serum ADMA levels in the gastritis rat model. The administration of a combination of standard eradication regimen and extract reduces serum ADMA levels and significantly improves the severity of gastritis rat model.