Rueda-Robles Ascensión, Rubio-Tomás Teresa, Plaza-Diaz Julio, Álvarez-Mercado Ana I
Center of Biomedical Research, Institute of Nutrition and Food Technology "José Mataix", University of Granada, Avda. del Conocimiento s/n., Armilla, 18016 Granada, Spain.
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Pathogens. 2021 Jul 10;10(7):875. doi: 10.3390/pathogens10070875.
is a Gram-negative bacterium that colonizes the stomach and can induce gastric disease and intra-gastric lesions, including chronic gastritis, peptic ulcers, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. This bacterium is responsible for long-term complications of gastric disease. The conjunction of host genetics, immune response, bacterial virulence expression, diet, micronutrient availability, and microbiome structure influence the disease outcomes related to chronic infection. In this regard, the consumption of unhealthy and unbalanced diets can induce microbial dysbiosis, which infection with may contribute to. However, to date, clinical trials have reported controversial results and current knowledge in this field is inconclusive. Here, we review preclinical studies concerning the changes produced in the microbiota that may be related to infection, as well as the involvement of diet. We summarize and discuss the last approaches based on the modulation of the microbiota to improve the negative impact of infection and their potential translation from bench to bedside.
是一种革兰氏阴性菌,可定植于胃部并引发胃部疾病和胃内病变,包括慢性胃炎、消化性溃疡、胃腺癌和黏膜相关淋巴组织淋巴瘤。这种细菌是胃部疾病长期并发症的病因。宿主遗传学、免疫反应、细菌毒力表达、饮食、微量营养素可利用性和微生物群结构的共同作用会影响与慢性感染相关的疾病结局。在这方面,不健康和不均衡饮食的摄入会导致微生物群失调,这可能与感染有关。然而,迄今为止,临床试验报告的结果存在争议,该领域的现有知识尚无定论。在此,我们综述了有关可能与感染相关的微生物群变化以及饮食影响的临床前研究。我们总结并讨论了基于调节微生物群以改善感染负面影响的最新方法及其从实验室到临床的潜在转化。