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补充乌鳢鱼提取物至一线根除方案对感染诱导的大鼠巨噬细胞移动抑制因子（MIF）表达的影响。

The effect of snakehead fish extract supplementation to first-line eradication regimen on macrophage migration inhibitory factor (MIF) expression in rats induced by infection.

作者信息

Yulizal O K, Lelo Aznan, Ilyas Syafruddin, Kusumawati Raden Lia

机构信息

Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.

Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.

出版信息

J Adv Vet Anim Res. 2020 May 8;7(2):209-217. doi: 10.5455/javar.2020.g411. eCollection 2020 Jun.

DOI:10.5455/javar.2020.g411
PMID:32607351
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7320804/
Abstract

OBJECTIVE

This work was organized to assess macrophage migration inhibitory factor (MIF) expression in snakehead fish extract supplementation to first-line eradication regimen in rats induced by infection.

MATERIALS AND METHODS

A total of 28 manly rats were haphazardly isolated equally into four groups. Group-1 was the control negative, and groups-2-4 were -infected groups. Group-2 was the control positive. Groups-3 and 4 were treated with first-line eradication regimen and first-line eradication regimen supplemented with snakehead fish extract, respectively. Immunoreactive scores (IRS) of MIF expression and eradication testing procedure were carried out. The comparison and difference between groups were analyzed by Kruskal-Wallis and Mann-Whitney U-test. A value of < 0.05 was considered to be a limit of significance.

RESULTS

The average IRS of MIF expression in group-2 was the highest among other groups ( < 0.05). Group-4 (supplemented by snakehead fish extract) had a lower median value IRS of MIF expression compared to group-3 [1.0 (0.0-2.0) 3.5 (2.0-6.0), = 0.004].

CONCLUSION

MIF expression was higher in rats induced by infection. Snakehead fish extract supplementation to first-line eradication regimen significantly reduces more MIF expression compared to a single administration of first-line eradication regimen in rats induced by infection.

摘要

目的

本研究旨在评估在感染诱导的大鼠一线根除方案中补充乌鳢鱼提取物时巨噬细胞移动抑制因子（MIF）的表达情况。

材料与方法

将28只雄性大鼠随机平均分为四组。第1组为阴性对照组，第2 - 4组为感染组。第2组为阳性对照组。第3组和第4组分别接受一线根除方案以及补充乌鳢鱼提取物的一线根除方案治疗。进行MIF表达的免疫反应评分（IRS）和根除测试程序。采用Kruskal - Wallis检验和Mann - Whitney U检验分析组间的比较和差异。P < 0.05被视为有统计学意义的界限。

结果

第2组中MIF表达的平均IRS在其他组中最高（P < 0.05）。与第3组相比，第4组（补充乌鳢鱼提取物）的MIF表达中位数IRS较低[1.0（0.0 - 2.0）对3.5（2.0 - 6.0），P = 0.004]。

结论

在感染诱导的大鼠中MIF表达较高。在感染诱导的大鼠中，与单独使用一线根除方案相比，在一线根除方案中补充乌鳢鱼提取物可显著降低更多的MIF表达。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dad6/7320804/4894155e2ad2/JAVAR-7-209-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dad6/7320804/fabfed479123/JAVAR-7-209-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dad6/7320804/4894155e2ad2/JAVAR-7-209-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dad6/7320804/fabfed479123/JAVAR-7-209-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dad6/7320804/4894155e2ad2/JAVAR-7-209-g002.jpg

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