三甲胺 N-氧化物，一种依赖于肠道微生物群的代谢物，与患有心血管疾病的老年衰弱患者相关。
Trimethylamine N-Oxide, a Gut Microbiota-Dependent Metabolite, is Associated with Frailty in Older Adults with Cardiovascular Disease.
机构信息
Department of Cardiology, Beijing Hospital, National Center of Gerontology, Beijing, People's Republic of China.
Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People's Republic of China.
出版信息
Clin Interv Aging. 2020 Sep 30;15:1809-1820. doi: 10.2147/CIA.S270887. eCollection 2020.
OBJECTIVE
Our study aimed to explore the association between trimethylamine N-oxide and frailty in older adults with cardiovascular disease.
PATIENTS AND METHODS
This cross-sectional study analyzed a total of 451 people aged 65 years or older who underwent comprehensive geriatric assessments. Frailty status was determined using a frailty index constructed with 48 variables according to the cumulative deficits model. Physical frailty and cognitive frailty were also assessed in detail. Fasting plasma TMAO was measured by mass spectrometry.
RESULTS
The proportion of frail subjects was 29.9% (135/451). Plasma TMAO levels were significantly higher in frail patients than in nonfrail individuals (4.04 [2.84-7.01] vs 3.21 [2.13-5.03] µM; p<0.001). Elevated plasma TMAO levels were independently associated with the likelihood of frailty (OR 2.12, 95% CI 1.01-4.38, p=0.046). Dose-response analysis revealed a linear association between the TMAO concentration and the OR for frailty. A 2-unit increase in TMAO was independently correlated with physical frailty (OR 1.23, 95% CI 1.08-1.41, p for trend 0.002) and cognitive frailty (OR 1.21, 95% CI 1.01-1.45, p for trend 0.04).
CONCLUSION
Elevated circulating TMAO levels are independently associated with frailty among older adults with cardiovascular disease.
目的
本研究旨在探讨心血管疾病老年患者中氧化三甲胺（TMAO）与虚弱之间的关系。
患者和方法
这是一项横断面研究，共分析了 451 名年龄在 65 岁及以上、接受全面老年评估的患者。使用根据累积缺陷模型构建的 48 个变量的虚弱指数来确定虚弱状态。还详细评估了身体虚弱和认知虚弱。通过质谱法测量空腹血浆 TMAO。
结果
虚弱患者的比例为 29.9%（135/451）。与非虚弱个体相比，虚弱患者的血浆 TMAO 水平显着升高（4.04 [2.84-7.01] vs 3.21 [2.13-5.03] µM；p<0.001）。升高的血浆 TMAO 水平与虚弱的可能性独立相关（OR 2.12，95%CI 1.01-4.38，p=0.046）。剂量反应分析显示 TMAO 浓度与虚弱的 OR 之间存在线性关系。TMAO 增加 2 个单位与身体虚弱（OR 1.23，95%CI 1.08-1.41，p 趋势 0.002）和认知虚弱（OR 1.21，95%CI 1.01-1.45，p 趋势 0.04）独立相关。
结论
心血管疾病老年患者中循环 TMAO 水平升高与虚弱独立相关。
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