Alqahtani Saleh A, Alghamdi Ibrahim G
Liver Transplantation Unit, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.
Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, MD, USA.
Cancer Manag Res. 2020 Oct 2;12:9527-9537. doi: 10.2147/CMAR.S268226. eCollection 2020.
Gallbladder cancer is generally rare but can be more common in some populations. The aim of this study was to present an analysis of gallbladder cancer epidemiology in Saudi Arabia.
A retrospective study of gallbladder cancer cases in Saudi Arabia from 2004 to 2015 was conducted. The gallbladder cancer data were accessed through the Saudi Cancer Registry (SCR) reports for 13 administrative regions. The number of gallbladder cancer cases with percentage, the crude incidence rate (CIR) and the age-standardised incidence rate (ASIR), stratified by regions, gender, and the years of diagnoses were analysed.
A total of 1678 gallbladder cancer cases, 702 in males and 976 in females, were registered between 2004 and 2015. Saudi women and men in the 75 and above age-group were found to have the highest diagnosis rate of gallbladder cancer. In males, the overall ASIR among Saudi males was 1.1 per 100,000 (95% CI, 0.9 to 1.2). The Eastern region had the highest overall ASIR at 1.5 per 100,000 males, followed by Tabuk and Riyadh at 1.4 and 1.3 higher than other regions (F(12,143)=1.930, P<0.001). The overall ASIR among Saudi females was 1.6 per 100,000 (95% CI, 1.4 to 1.7). Riyadh had the highest overall ASIR at 2.4 per 100,000 females, followed by the Eastern region, and Qassim at 1.9 and 1.5, respectively, all higher than other provinces of the country (F(12,143)=2.496, P<0.005). The ASIR and CIR were lower among males than females (ratio 0.7).
Gallbladder cancer incidence is relatively low in Saudi Arabia. The rates were higher in females than males. ASIR showed variations between different provinces of Saudi Arabia. In females, the highest ASIR was in Riyadh. In males, ASIR was highest in the Eastern region of Saudi Arabia.
胆囊癌总体较为罕见，但在某些人群中可能更为常见。本研究的目的是对沙特阿拉伯的胆囊癌流行病学进行分析。
对2004年至2015年沙特阿拉伯的胆囊癌病例进行回顾性研究。通过沙特癌症登记处（SCR）针对13个行政区的报告获取胆囊癌数据。分析了按地区、性别和诊断年份分层的胆囊癌病例数、百分比、粗发病率（CIR）和年龄标准化发病率（ASIR）。
2004年至2015年期间共登记了1678例胆囊癌病例，其中男性702例，女性976例。发现75岁及以上年龄组的沙特女性和男性胆囊癌诊断率最高。在男性中，沙特男性的总体ASIR为每10万人1.1例（95%可信区间，0.9至1.2）。东部地区的总体ASIR最高，为每10万男性1.5例，其次是塔布克和利雅得，分别为1.4和1.3，高于其他地区（F(12,143)=1.930，P<0.001）。沙特女性的总体ASIR为每10万人1.6例（95%可信区间，1.4至1.7）。利雅得的总体ASIR最高，为每10万女性2.4例，其次是东部地区和卡西姆，分别为1.9和1.5，均高于该国其他省份（F(12,143)=2.496，P<0.005）。男性的ASIR和CIR低于女性（比率为0.7）。
沙特阿拉伯的胆囊癌发病率相对较低。女性的发病率高于男性。ASIR在沙特阿拉伯的不同省份之间存在差异。在女性中，ASIR最高的是利雅得。在男性中，ASIR最高的是沙特阿拉伯东部地区。
