Alghamdi Ibrahim G, Almadi Majid, Alsohaibani Fahad, Mosli Mahmoud, De Vol Edward B, Abaalkhail Faisal, AlSaif Faisal A, Al-Hamoudi Waleed K, Al-Sanea Nasser, Hassanain Mazen, Alqahtani Saleh A
Public Health Department, College of Applied Medical Sciences, University of Al-Baha, Al-Baha, Saudi Arabia.
Division of Gastroenterology, Department of Medicine, College of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.
Clin Exp Gastroenterol. 2021 Feb 10;14:45-57. doi: 10.2147/CEG.S289269. eCollection 2021.
Over the last decades, the incidence of pancreatic cancer has increased, particularly in countries with a higher socioeconomic status. The present work aimed to provide detailed epidemiological data on the incidence of pancreatic cancer in Saudi Arabia.
In this retrospective descriptive study, the epidemiological data on pancreatic cancer cases diagnosed in 13 administrative regions of Saudi Arabia between January 2004 and December 2015 were extracted from the Saudi Cancer Registry. The frequency, the crude incidence rate (CIR), and the age-standardized incidence rate (ASIR), stratified by geographical region, gender, and the year of diagnosis, were analyzed.
From January 2004 to December 2015, a total of 2338 cases of pancreatic cancer were registered, including 1443 males and 895 females. The overall CIR was 1.28/100,000 among males and 0.80/100,000 in females, with an overall ASIR of 2.26 and 1.41/100,000 for males and females, respectively. Higher ASIR and CIR were observed among males than females (ratio 1.6). In both genders, the ASIR of pancreatic cancer increased with increasing age, with the highest incidence in patients aged 70 years or more. The ASIR in the Eastern Region (3.2/100,000) and the regions of Riyadh (3.0/100,000) and Tabuk (2.6/100,000) proved to be significantly higher than in the other regions of the country. Among women, the ASIR was significantly higher in Riyadh (2.3/100,000), the northern region (2.2/100,000), and Tabuk (2.0/100,000).
This study revealed a slight increase of the CIR and ASIR of pancreatic cancer among males and females of the Saudi population. Eastern region, Riyadh, and Tabuk had the highest overall ASIRs of pancreatic cancer among males, Riyadh, Northern region, and Tabuk among Saudi females. The area least affected by pancreatic cancer was observed in Jazan among male and female Saudis. The rates of pancreatic cancer in Saudi Arabia were significantly higher among males compared with female Saudis. Further analytical studies are needed to identify the potential risk factors for pancreatic cancer among the Saudi population.
在过去几十年中，胰腺癌的发病率有所上升，尤其是在社会经济地位较高的国家。本研究旨在提供沙特阿拉伯胰腺癌发病率的详细流行病学数据。
在这项回顾性描述性研究中，从沙特癌症登记处提取了2004年1月至2015年12月期间在沙特阿拉伯13个行政区诊断出的胰腺癌病例的流行病学数据。分析了按地理区域、性别和诊断年份分层的发病率、粗发病率（CIR）和年龄标准化发病率（ASIR）。
2004年1月至2015年12月，共登记了2338例胰腺癌病例，其中男性1443例，女性895例。男性的总体CIR为1.28/10万，女性为0.80/10万，男性和女性的总体ASIR分别为2.26和1.41/10万。男性的ASIR和CIR高于女性（比例为1.6）。在两性中，胰腺癌的ASIR均随年龄增长而增加，70岁及以上患者的发病率最高。东部地区（3.2/10万）、利雅得地区（3.0/10万）和塔布克地区（2.6/10万）的ASIR明显高于该国其他地区。在女性中，利雅得（2.3/10万）、北部地区（2.2/10万）和塔布克（2.0/10万）的ASIR明显较高。
本研究显示沙特人群中男性和女性胰腺癌的CIR和ASIR略有上升。东部地区、利雅得和塔布克在男性中胰腺癌的总体ASIR最高，利雅得、北部地区和塔布克在沙特女性中最高。在沙特男性和女性中，吉赞受胰腺癌影响最小。沙特男性胰腺癌的发病率明显高于沙特女性。需要进一步的分析研究来确定沙特人群中胰腺癌的潜在危险因素。
