Kumar Poludasari Shravan, Vidya Rachakonda, Jageer Manashwini
Department of Pharmacy Practice, Malla Reddy Pharmacy College, Dhulapally, Secunderabad, Telangana, India.
EJIFCC. 2020 Sep 29;31(3):242-247. eCollection 2020 Sep.
Tuberculosis is a potentially communicable disease that can infect any organ in the body such as bones, kidney, intestine but primarily involves lung parenchyma (Pulmonary tuberculosis). The prevalence of TB is 256 per 100,000 population in India. Hepatotoxicity, gastrointestinal and neurological disorders were some the Adverse Drug Reactions (ADR's) reported that significantly increases the mortality rate which leads to decreased efficacy of the treatment. Hepatotoxicity is the most commonly reported ADR in patients treated with anti-tubercular drugs such as isoniazid, rifampicin and pyrazinamide. Clinical manifestations of hepatotoxicity include abdominal pain, nausea, vomiting, and jaundice. We report the case of a 19-year-old female with complaints of yellowish discoloration of sclera for 45 days associated with vomitings for one week. She had a past medical history of tuberculosis for which she was advised with DOT (Direct Observation Therapy) regimen. A diagnosis of Anti-Tuberculosis Treatment (ATT) - induced hepatotoxicity was made based on the clinical examination and laboratory investigations which was successfully managed by providing supportive care and symptomatic treatment.
结核病是一种具有潜在传染性的疾病，可感染身体的任何器官，如骨骼、肾脏、肠道，但主要累及肺实质（肺结核）。印度的结核病患病率为每10万人中有256例。肝毒性、胃肠道和神经系统疾病是报告的一些不良反应，这些反应显著增加了死亡率，导致治疗效果下降。肝毒性是使用异烟肼、利福平、吡嗪酰胺等抗结核药物治疗的患者中最常报告的不良反应。肝毒性的临床表现包括腹痛、恶心、呕吐和黄疸。我们报告了一例19岁女性病例，该患者主诉巩膜黄染45天，伴有呕吐一周。她有结核病病史，为此接受了直接观察治疗（DOT）方案。根据临床检查和实验室检查，诊断为抗结核治疗（ATT）引起的肝毒性，通过提供支持性护理和对症治疗成功进行了处理。
