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Patterning inconsistencies restrict the true potential of dopaminergic neurons derived from human induced pluripotent stem cells.

作者信息

Mahajani Sameehan, Bähr Mathias, Kügler Sebastian

机构信息

Department of Neurology; Center for Nanoscale Microscopy and Molecular Physiology of the Brain at Department of Neurology, University Medical Center Göttingen, Göttingen, Germany; Current affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.

Department of Neurology, University Medical Center Göttingen; Center for Nanoscale Microscopy and Molecular Physiology of the Brain at Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.

出版信息

Neural Regen Res. 2021 Apr;16(4):692-693. doi: 10.4103/1673-5374.295316.

DOI:10.4103/1673-5374.295316
PMID:33063729
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8067935/
Abstract
摘要

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本文引用的文献

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Homogenous generation of dopaminergic neurons from multiple hiPSC lines by transient expression of transcription factors.通过瞬时表达转录因子从多种 hiPSC 系同源产生多巴胺能神经元。
Cell Death Dis. 2019 Nov 27;10(12):898. doi: 10.1038/s41419-019-2133-9.
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Lamin B1 levels modulate differentiation into neurons during embryonic corticogenesis.核层蛋白 B1 水平调节胚胎皮质发生过程中的神经元分化。
Sci Rep. 2017 Jul 7;7(1):4897. doi: 10.1038/s41598-017-05078-6.
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Isolation of human induced pluripotent stem cell-derived dopaminergic progenitors by cell sorting for successful transplantation.通过细胞分选分离人诱导多能干细胞衍生的多巴胺能祖细胞，以实现成功移植。
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Stem Cells Transl Med. 2013 Jun;2(6):473-9. doi: 10.5966/sctm.2012-0133. Epub 2013 May 8.
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Small molecules, big roles -- the chemical manipulation of stem cell fate and somatic cell reprogramming.小分子，大作用——化学操纵干细胞命运和体细胞重编程。
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Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions.在特定条件下从人类胚胎干细胞中生成具有区域特异性的神经祖细胞和功能性神经元。
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Specification of midbrain dopamine neurons from primate pluripotent stem cells.从中枢神经多巴胺神经元从灵长类多能干细胞的规格。
Stem Cells. 2012 Aug;30(8):1655-63. doi: 10.1002/stem.1152.
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Small molecules greatly improve conversion of human-induced pluripotent stem cells to the neuronal lineage.小分子极大地提高了人诱导多能干细胞向神经元谱系的转化。
Stem Cells Int. 2012;2012:140427. doi: 10.1155/2012/140427. Epub 2012 Apr 10.
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Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease.人胚胎干细胞衍生的多巴胺神经元在帕金森病动物模型中有效移植。
Nature. 2011 Nov 6;480(7378):547-51. doi: 10.1038/nature10648.
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Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells.通过胚胎干细胞中Lmx1a的表达高效生成中脑多巴胺能神经元。
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