酵母DNA修复基因RAD6编码一种泛素结合酶。
The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme.
作者信息
Jentsch S, McGrath J P, Varshavsky A
出版信息
Nature. 1987;329(6135):131-4. doi: 10.1038/329131a0.
DOI:10.1038/329131a0
PMID:3306404
Abstract
The RAD6 gene of the yeast Saccharomyces cerevisiae is required for a variety of cellular functions including DNA repair. The discovery that the RAD6 gene product can catalyse the covalent attachment of ubiquitin to other proteins suggests that the multiple functions of the RAD6 protein are mediated by its ubiquitin-conjugating activity.
摘要
酿酒酵母的RAD6基因是多种细胞功能（包括DNA修复）所必需的。RAD6基因产物能够催化泛素与其他蛋白质的共价连接，这一发现表明RAD6蛋白的多种功能是由其泛素结合活性介导的。
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