Fielding School of Public Health, University of California Los Angeles, Los Angeles, California, USA.
Burke, Virginia, USA.
Environ Mol Mutagen. 2020 Nov;61(9):910-921. doi: 10.1002/em.22412. Epub 2020 Oct 26.
All the cells in our bodies are derived from the germ cells of our parents, just as our own germ cells become the bodies of our children. The integrity of the genetic information inherited from these germ cells is of paramount importance in establishing the health of each generation and perpetuating our species into the future. There is a large and growing body of evidence strongly suggesting the existence of substances that may threaten this integrity by acting as human germ cell mutagens. However, there generally are no absolute regulatory requirements to test agents for germ cell effects. In addition, the current regulatory testing paradigms do not evaluate the impacts of epigenetically mediated intergenerational effects, and there is no regulatory framework to apply new and emerging tests in regulatory decision making. At the 50th annual meeting of the Environmental Mutagenesis and Genomics Society held in Washington, DC, in September 2019, a workshop took place that examined the heritable effects of hazardous exposures to germ cells, using tobacco smoke as the example hazard. This synopsis provides a summary of areas of concern regarding heritable hazards from tobacco smoke exposures identified at the workshop and the value of the Clean Sheet framework in organizing information to address knowledge and testing gaps.
我们体内的所有细胞都源自父母的生殖细胞，就像我们自己的生殖细胞将成为我们孩子的身体一样。从这些生殖细胞中遗传的遗传信息的完整性对于每一代的健康和我们物种的未来延续至关重要。有大量越来越多的证据强烈表明，可能存在某些物质会通过充当人类生殖细胞诱变剂来威胁这种完整性。然而，通常没有绝对的监管要求来测试对生殖细胞有影响的物质。此外，当前的监管测试范式并未评估表观遗传介导的代际影响，也没有监管框架可将新出现的测试应用于监管决策。在 2019 年 9 月于华盛顿特区举行的第 50 届环境诱变剂和基因组学会年会上，举办了一个研讨会，该研讨会以烟草烟雾为例，研究了生殖细胞受到危险暴露的可遗传影响。这篇概要提供了一个概述，介绍了在研讨会上确定的与烟草烟雾暴露相关的可遗传危害的关注领域，以及“清洁纸页”框架在组织信息以解决知识和测试差距方面的价值。
