Vascular Dynamics Lab, McMaster University, Hamilton, Ontario, Canada.
Am J Physiol Heart Circ Physiol. 2021 Jan 1;320(1):H29-H35. doi: 10.1152/ajpheart.00607.2020. Epub 2020 Oct 16.
Sleep is critical for the maintenance of physiological homeostasis and, as such, inadequate sleep beckons a myriad of pathologies. Sleep deprivation is a growing health concern in contemporary society since short sleep durations are associated with increased cardiovascular disease risk and atherosclerotic plaque development. Vascular endothelial dysfunction is an antecedent to atherosclerosis and cardiovascular disease. Herein, we review seminal literature indicating that short sleep durations attenuate endothelial function and explore more recent evidence indicating that sleep deprivation perturbs autonomic balance and the circadian rhythmicity of peripheral vascular clock components. We further examine literature that indicates a mechanistic link between short sleep duration and endothelial dysfunction and subsequent morbidity. Understanding the mechanisms that regulate endothelial function in the context of sleep deprivation facilitates the development and optimization of interventions, such as exercise, that mitigate the ramifications of inadequate sleep on vascular function and cardiovascular health.Listen to this article's corresponding podcast at https://ajpheart.podbean.com/e/sleep-deprivation-and-endothelial-function/.
睡眠对于维持生理平衡至关重要，因此，睡眠不足会引发多种疾病。在当代社会，睡眠不足是一个日益严重的健康问题，因为睡眠时间短与心血管疾病风险增加和动脉粥样硬化斑块发展有关。血管内皮功能障碍是动脉粥样硬化和心血管疾病的前兆。在此，我们回顾了一些重要文献，表明睡眠时间短会减弱内皮功能，并探讨了最近的证据表明，睡眠剥夺会扰乱自主平衡和外周血管时钟成分的昼夜节律性。我们进一步研究了文献，表明短睡眠持续时间与内皮功能障碍以及随后的发病率之间存在机制联系。了解睡眠剥夺背景下调节内皮功能的机制有助于开发和优化干预措施，如运动，以减轻睡眠不足对血管功能和心血管健康的影响。在 https://ajpheart.podbean.com/e/sleep-deprivation-and-endothelial-function/ 上收听本文的相应播客。
