Department of Neurobiology and Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Neuron. 2013 Oct 30;80(3):624-32. doi: 10.1016/j.neuron.2013.10.023.
Over the past 25 years, the broad field of epigenetics and, over the past decade in particular, the emerging field of neuroepigenetics have begun to have tremendous impact in the areas of learned behavior, neurotoxicology, CNS development, cognition, addiction, and psychopathology. However, epigenetics is such a new field that in most of these areas the impact is more in the category of fascinating implications as opposed to established facts. In this brief commentary, I will attempt to address and delineate some of the open questions and areas of opportunity that discoveries in epigenetics are providing to the discipline of neuroscience.
在过去的 25 年中,广泛的表观遗传学领域,特别是在过去的十年中,新兴的神经表观遗传学领域开始在学习行为、神经毒理学、中枢神经系统发育、认知、成瘾和精神病理学等领域产生巨大影响。然而,表观遗传学是一个如此新的领域,在大多数这些领域中,其影响更多地属于迷人的暗示,而不是既定的事实。在这篇简短的评论中,我将尝试解决并阐述在神经科学领域,表观遗传学的发现所提供的一些悬而未决的问题和机会领域。