Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
J Am Med Dir Assoc. 2021 Apr;22(4):809-815. doi: 10.1016/j.jamda.2020.08.035. Epub 2020 Oct 14.
To evaluate the efficacy of daily consumption of fortified yogurt with beta-Hydroxy beta-Methyl Butyrate (HMB) and vitamins D and C on measures of sarcopenia, inflammation, and quality of life in sarcopenic older adults.
In this 12-week randomized double-blind controlled trial, participants received either yogurt fortified with 3 g HMB, 1000 IU vitamin D, and 500 mg vitamin C in the intervention group (n = 33) or plain yogurt in the control group (n = 33).
A total of 66 older adults with sarcopenia recruited from the community in Shiraz, Iran.
Body composition, muscle strength, and functionality were measured using Dual-energy-X-ray Absorptiometry (DXA), hydraulic handgrip dynamometer, and usual gait speed, respectively. Serum concentrations of vitamin D, insulin-like growth factor-1 (IGF-1), C-reactive protein (hs-CRP), malondialdehyde, and insulin were measured at baseline and after 12 weeks. Health-related quality of life (HRQoL) was also evaluated using SF-12 questionnaire.
Consumption of fortified yogurt was associated with improvement in handgrip strength [mean change (95% confidence interval) 4.36 (3.35-5.37) vs. 0.97 (-0.04 to 1.99)] and gait speed [0.10 (0.07-0.13) vs. 0.01 (0.00-0.04)] in the intervention group compared with the control group (P < .001). In addition, the results revealed a significant increase in vitamin D and IGF-1 levels in the intervention group (P < .001). The nutritional intervention significantly prevented any increase in the serum concentration of hs-CRP compared with the control group (P = .033). The results also showed a more significant decrease in the malondialdehyde level in the intervention group compared with the control (P = .008). Moreover, there were significant differences between the 2 groups regarding physical aspects of HRQoL (P = .035).
A novel dairy product fortified with HMB, vitamin D, and vitamin C not only could enhance muscle strength and functionality, but also modulate anabolic and inflammatory conditions as well as quality of life. This study suggested that specific nutritional interventions alone could be beneficial, especially for those who are unable to exercise.
评估富含β-羟基-β-甲基丁酸（HMB）、维生素 D 和 C 的强化酸奶对肌少症老年人肌少症、炎症和生活质量措施的疗效。
在这项为期 12 周的随机双盲对照试验中，参与者分别接受强化酸奶（干预组，n=33）或普通酸奶（对照组，n=33）治疗。干预组酸奶中添加 3 g HMB、1000 IU 维生素 D 和 500 mg 维生素 C。
共有 66 名来自伊朗设拉子社区的肌少症老年人参与了这项研究。
使用双能 X 射线吸收仪（DXA）、液压握力计和常规步速分别测量身体成分、肌肉力量和功能。分别在基线和 12 周后测量血清维生素 D、胰岛素样生长因子-1（IGF-1）、C 反应蛋白（hs-CRP）、丙二醛和胰岛素的浓度。还使用 SF-12 问卷评估了健康相关生活质量（HRQoL）。
与对照组相比，强化酸奶的摄入与握力（平均变化（95%置信区间）4.36（3.35-5.37）与 0.97（-0.04 至 1.99））和步速（0.10（0.07-0.13）与 0.01（0.00-0.04））的改善有关（P<0.001）。此外，结果显示干预组维生素 D 和 IGF-1 水平显著升高（P<0.001）。与对照组相比，营养干预显著阻止了 hs-CRP 血清浓度的任何升高（P=0.033）。结果还表明，与对照组相比，干预组丙二醛水平显著下降（P=0.008）。此外，两组在 HRQoL 的生理方面存在显著差异（P=0.035）。
一种新型强化乳制品，富含 HMB、维生素 D 和 C，不仅可以增强肌肉力量和功能，还可以调节合成代谢和炎症状态以及生活质量。本研究表明，单独的特定营养干预可能是有益的，特别是对那些无法运动的人。
