Département de Diététique et de Nutrition, Hôpital Saint-Charles, Beirut, Lebanon.
Université Clermont Auvergne, INRA, UNH, Unité de Nutrition Humaine, CRNH Auvergne, 63000, Clermont-Ferrand, France.
Arch Osteoporos. 2018 Dec 19;14(1):4. doi: 10.1007/s11657-018-0553-2.
Previous studies have shown that improving vitamin D status among the elderly may lead to an improvement in muscle mass and muscle strength. In our study, vitamin D supplementation showed significant improvements in vitamin D concentrations as well as appendicular muscle mass in pre-sarcopenic older Lebanese people. However, we found no significant effect on muscle strength.
Improving vitamin D status might improve muscle function and muscle mass that lead to sarcopenia in older subjects. The aim of this randomized, controlled, double-blind study was to examine the effect of vitamin D supplementation on handgrip strength and appendicular skeletal muscle mass in pre-sarcopenic older Lebanese subjects. We also examined whether this effect differs in normal vs. obese subjects.
Participants (n = 128; 62 men and 66 women) deficient in vitamin D (25(OH)D = 12.92 ± 4.3 ng/ml) were recruited from Saint Charles Hospital, Beirut, Lebanon. The participants were given a supplement of 10,000 IU of cholecalciferol (vitamin D group; n = 64) to be taken three times a week or a placebo tablet (placebo group; n = 64) for 6 months. One hundred fifteen subjects completed the study: 59 had normal weight, while 56 were obese. Strength and functional assessment and biochemical analysis were performed at the start and after 6 months.
Compared to placebo, the vitamin D supplemented group showed significant improvements in appendicular skeletal muscle mass (ASMM) (P < 0.001) but not in handgrip strength (P = 0.2901). ANCOVA for ASMM adjusting for obesity and including the interaction between obesity and vitamin D showed a significant interaction. The increase in ASMM with vitamin D in normal-weight subjects was higher than that of obese subjects (B = 35.09 vs. B = 2.19).
Treatment with vitamin D showed beneficial effects on appendicular muscle mass in pre-sarcopenic older Lebanese men and women. However, it had no effect on muscle strength relative to placebo. This trial was registered at isrctn.org as ISRCTN16665940.
改善维生素 D 状态可能会改善肌肉功能和肌肉质量，从而导致老年受试者出现肌肉减少症。本随机、对照、双盲研究的目的是研究维生素 D 补充对预肌肉减少症的老年黎巴嫩受试者握力和四肢骨骼肌质量的影响。我们还研究了这种影响在正常体重和肥胖受试者中是否存在差异。
参与者（n=128；62 名男性和 66 名女性）维生素 D 缺乏（25（OH）D=12.92±4.3ng/ml），从黎巴嫩贝鲁特圣查尔斯医院招募。参与者每周服用三次 10000IU 的胆钙化醇（维生素 D 组；n=64）或安慰剂片（安慰剂组；n=64），持续 6 个月。115 名受试者完成了研究：59 名受试者体重正常，56 名受试者肥胖。在开始和 6 个月后进行了力量和功能评估以及生化分析。
与安慰剂相比，维生素 D 补充组的四肢骨骼肌质量（ASMM）显著增加（P<0.001），但握力无显著变化（P=0.2901）。调整肥胖并包括维生素 D 与肥胖之间相互作用的 ASMM 的协方差分析显示存在显著的相互作用。在体重正常的受试者中，维生素 D 对 ASMM 的增加高于肥胖受试者（B=35.09 与 B=2.19）。
维生素 D 治疗对预肌肉减少症的老年黎巴嫩男女四肢肌肉质量有有益影响。然而，与安慰剂相比，它对肌肉力量没有影响。该试验在 isrctn.org 上注册为 ISRCTN16665940。
