一项横断面研究探讨了全氟化学品暴露与雌激素受体失调相关癌症之间的关联。

A cross-sectional study of the association between perfluorinated chemical exposure and cancers related to deregulation of estrogen receptors.

机构信息

Department of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, TN, USA.

Department of Community and Behavioral Health, College of Public Health, East Tennessee State University, Johnson City, TN, USA.

出版信息

Environ Res. 2021 May;196:110329. doi: 10.1016/j.envres.2020.110329. Epub 2020 Oct 14.

DOI:10.1016/j.envres.2020.110329

PMID:33068574

Abstract

BACKGROUND

Environmental exposures acting through different mechanisms have been linked with a number of cancers. Perfluoroalkyl chemicals (PFCs) are endocrine disrupting chemicals affecting estrogen homeostasis.

OBJECTIVES

We examined the association between PFCs and a group of estrogen related cancers and explored if increased non-occupational exposure was associated with increased odds of developing these cancers. We also explored which of these chemical exposures was more correlated with each cancer.

METHODS

Using data from the National Health and Nutrition Examination Survey (NHANES), we selected participants ≥ 20 years of age. Our outcome variable was presence or absence of breast, prostate, ovarian and uterine cancer (yes/no); our exposure variables were serum PFCs. Logistic regression models were used in investigating the association between PFCs and cancer types and between quartiles of PFCs exposure concentrations and presence or absence of cancer while adjusting for covariates. Discriminant analysis was used to assess the correlation between individual PFCs compounds and individual cancer types.

RESULTS

PFCs were associated with increased odds of ovarian cancer; PFOA: 1.02(1.01, 1.02), PFOS: 1.01 (1.012, 1.013), PFHS 1.031 (1.030, 1.033), PFDE: 1.29(1.27, 1.30) and increased odds of breast cancer; PFOA: 1.089(1.089, 1.09), PFOS: 1.011(1.011, 1.011), PFNA: 1.031(1.030, 1.033), PFHS: 1.02 (1.02, 1.02), PFDE: 1.19(1.18, 1.19). PFCs were not associated with increased odds of prostate or uterine cancers. Comparing the odds in quartile 4 to quartile 1 for ovarian cancer, PFOA: 1.77(1.75,1.79), PFOS: 2.25(2.22, 2.28), PFHS: 1.86(1.84, 1.88), PFDE: 2.11(2.09, 2.14). For breast cancer, PFOA: 2.30(2.28, 2.31), PFOS: 1.47(1.46, 1.48), PFNA: 1.04(1.03, 1.05), PFHS:7.07(6.97,7.17), PFDE: 1.38(1.37, 1.39). PFOA was more correlated with breast cancer (0.7) and PFHS was more correlated with ovarian cancer (0.9).

DISCUSSION

PFCs were associated with increased odds of ovarian and breast cancers with a positive dose-response relationship. PFOA was more correlated with breast cancer and PFHS more with ovarian cancer.

摘要

背景

通过不同机制作用的环境暴露与许多癌症有关。全氟烷基化学品（PFCs）是影响雌激素稳态的内分泌干扰化学物质。

目的

我们研究了 PFCs 与一组与雌激素相关的癌症之间的关联，并探讨了非职业性暴露增加是否与这些癌症的发病风险增加有关。我们还探讨了这些化学物质暴露中哪一种与每种癌症的相关性更强。

方法

使用来自国家健康和营养检查调查（NHANES）的数据，我们选择了年龄≥20 岁的参与者。我们的结局变量是存在或不存在乳腺癌、前列腺癌、卵巢癌和子宫癌（是/否）；我们的暴露变量是血清 PFCs。使用逻辑回归模型调查 PFCs 与癌症类型之间的关联以及 PFCs 暴露浓度四分位数与癌症存在与否之间的关联，同时调整协变量。判别分析用于评估单个 PFC 化合物与单个癌症类型之间的相关性。

结果

PFCs 与卵巢癌发病风险增加相关；PFOA：1.02（1.01，1.02），PFOS：1.01（1.012，1.013），PFHS：1.031（1.030，1.033），PFDE：1.29（1.27，1.30）；与乳腺癌发病风险增加相关；PFOA：1.089（1.089，1.09），PFOS：1.011（1.011，1.011），PFNA：1.031（1.030，1.033），PFHS：1.02（1.02，1.02），PFDE：1.19（1.18，1.19）。PFCs 与前列腺癌或子宫癌发病风险增加无关。与卵巢癌四分位数 4 与四分位数 1 相比，PFOA：1.77（1.75，1.79），PFOS：2.25（2.22，2.28），PFHS：1.86（1.84，1.88），PFDE：2.11（2.09，2.14）。对于乳腺癌，PFOA：2.30（2.28，2.31），PFOS：1.47（1.46，1.48），PFNA：1.04（1.03，1.05），PFHS：7.07（6.97，7.17），PFDE：1.38（1.37，1.39）。PFOA 与乳腺癌相关性更强（0.7），PFHS 与卵巢癌相关性更强（0.9）。