Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, 3010, Australia.
Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University Alpert Medical School, Providence, RI, 02912, USA.
Curr Opin Immunol. 2021 Feb;68:48-53. doi: 10.1016/j.coi.2020.08.009. Epub 2020 Oct 14.
Group 1 innate lymphoid cells (ILCs) comprise the natural killer (NK) cells and ILC1s. Both cells co-exist in peripheral tissues and despite effort to characterize the molecular identity and developmental pathways of ILC1s, their relationship with NK cells remains elusive. ILC1s and NK cells share many common features and analysis of ILC1s in tissues revealed a great heterogeneity and distinct transcriptional requirement of each ILC1 subsets complexifying the organization of this group. Here, we discuss whether ILC1 and NK cells can be considered as distinct lineages based on their origin, location, phenotype or transcriptional regulation. Discrimination of NK cells and ILC1s represent an important challenge to unravel the individual functions of these cells during infection and tumor immunosurveillance.
第一组固有淋巴细胞 (ILC) 包括自然杀伤 (NK) 细胞和 ILC1。这两种细胞都存在于外周组织中，尽管人们努力描述 ILC1 的分子特征和发育途径，但它们与 NK 细胞的关系仍然难以捉摸。ILC1 和 NK 细胞有许多共同特征，对组织中的 ILC1 分析显示，每个 ILC1 亚群的转录要求都存在很大的异质性，这使得该组的组织更加复杂。在这里，我们讨论了基于起源、位置、表型或转录调控，ILC1 和 NK 细胞是否可以被视为不同的谱系。区分 NK 细胞和 ILC1 是揭示这些细胞在感染和肿瘤免疫监视过程中个体功能的重要挑战。
