[环状RNA在血液系统恶性肿瘤中的研究进展——综述]

[Recent Research Progress on CircRNA in Hematological Malignancies--Review].

作者信息

Bai Xue, Chen Xiao-Feng, Li Zhong-Yu, Wang Meng, Li Jia-Jia

机构信息

Department of Hematology, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233003, Anhui Province, China.

Department of Hematology, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233003, Anhui Province, China. E-mail:

出版信息

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2023 Jun;31(3):927-930. doi: 10.19746/j.cnki.issn.1009-2137.2023.03.047.

DOI:10.19746/j.cnki.issn.1009-2137.2023.03.047

PMID:37356963

Abstract

Most hematological tumors have high-grade malignancy and low cure rate, requiring new molecular markers for detection and evaluation. Circular RNAs (circRNAs) are a class of non-coding RNAs with covalently closed-loop structures, which participate in gene transcription and translation by binding to microRNAs and proteins. In recent years, with the deepening research on circRNAs, circRNAs have been found to play an important role in hematological malignancies. In this review, the latest research progress on the function and molecular mechanism of circRNAs in hematological malignancies was systematically summarized, and it was found that circRNAs may be potential new biomarkers and therapeutic targets in hematological malignancies.

摘要

大多数血液系统肿瘤具有高度恶性且治愈率低，需要新的分子标志物用于检测和评估。环状RNA（circRNA）是一类具有共价闭合环状结构的非编码RNA，其通过与微小RNA和蛋白质结合参与基因转录和翻译。近年来，随着对circRNA研究的深入，发现circRNA在血液系统恶性肿瘤中发挥重要作用。本文综述系统总结了circRNA在血液系统恶性肿瘤中功能及分子机制的最新研究进展，发现circRNA可能是血液系统恶性肿瘤潜在的新型生物标志物和治疗靶点。