Women and Infants Research Foundation, Carson House, King Edward Memorial Hospital, 374 Bagot Road, Subiaco, Perth, Australia.
Women and Infants Research Foundation, Carson House, King Edward Memorial Hospital, 374 Bagot Road, Subiaco, Perth, Australia; Division of Obstetrics and Gynaecology, University of Western Australia, King Edward Memorial Hospital, 374 Bagot Road, Subiaco, Perth, WA, Australia, 6008.
Environ Res. 2021 Apr;195:110313. doi: 10.1016/j.envres.2020.110313. Epub 2020 Oct 16.
Phthalates are ubiquitous environmental chemicals with predominantly anti-androgenic, and potentially obesogenic effects. We hypothesised that antenatal phthalate exposure may influence subsequent boy's growth and body composition through childhood and adolescence. Among 1399 singleton males from the Raine Study, 410 had maternal serum and at least one height, BMI or DEXA outcome available after birth and up to 20 years of age. Maternal serum collected at 18 and 34 weeks' gestation was pooled, and analyzed for concentrations of 32 metabolites of 15 phthalate diesters. Their serum concentrations were categorized into undetectable/detectable levels or tertiles. Linear mixed models were used to determine associations between maternal serum phthalate levels and longitudinal height and body mass index (BMI) z-scores in boys from birth to 20 years of age (n = 250 and n = 295 respectively). Linear regression was used to determine associations between maternal phthalate levels and deviation from mid-parental height (n = 177) and DEXA scan outcomes (n = 191) at the 20 year follow-up. Weak positive associations of participants height z-score increase were detected with exposure to some phthalate metabolites in particular to the lower molecular weight phthalate metabolites. Less consistent findings, by mixed model analyses, were detected for BMI and body composition, by dual energy X-ray absorptiometry (DEXA), with some positive associations of phthalate metabolites with BMI and some negative associations with DEXA fat tissue measures, although no consistent findings were evident. In conclusion, we derived some associations of childhood growth with prenatal phthalate exposure, particularly with respect to the lower molecular weight phthalate metabolites.
邻苯二甲酸酯是普遍存在于环境中的化学物质，主要具有抗雄激素作用，并且可能具有肥胖作用。我们假设产前邻苯二甲酸酯暴露可能会通过儿童和青少年期影响随后男孩的生长和身体成分。在 Raine 研究的 1399 名单身男性中，有 410 名男性在出生后至 20 岁时具有母亲血清和至少一项身高、BMI 或 DEXA 结果。在妊娠 18 周和 34 周时采集母亲的血清，并对 15 种邻苯二甲酸二酯的 32 种代谢物的浓度进行分析。将他们的血清浓度分为不可检测/可检测水平或三分位。线性混合模型用于确定母亲血清邻苯二甲酸酯水平与男孩从出生到 20 岁的纵向身高和体重指数（BMI）Z 分数之间的关联（分别为 n=250 和 n=295）。线性回归用于确定母亲邻苯二甲酸酯水平与 20 年随访时中父母身高偏差（n=177）和 DEXA 扫描结果（n=191）之间的关联。在参与者身高 Z 分数增加方面，与某些邻苯二甲酸酯代谢物，特别是低分子量邻苯二甲酸酯代谢物的暴露呈弱正相关。通过混合模型分析检测到 BMI 和身体成分的结果不一致，通过双能 X 射线吸收法（DEXA），一些邻苯二甲酸酯代谢物与 BMI 呈正相关，一些与 DEXA 脂肪组织测量值呈负相关，尽管没有一致的发现。总之，我们得出了一些与儿童生长相关的产前邻苯二甲酸酯暴露的关联，特别是与低分子量邻苯二甲酸酯代谢物相关的关联。
