College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Division of Medical Oncology, Mayo Clinic, Rochester, MN, USA.
Crit Rev Oncol Hematol. 2020 Dec;156:103093. doi: 10.1016/j.critrevonc.2020.103093. Epub 2020 Sep 22.
To review and summarize the available literature on the management of chemotherapy-induced alopecia (CIA) including complementary and alternative medicine (CAM), and to present CIA's effect on quality of life (QoL).
Nine databases were searched for CIA-related keywords, including the effect on QoL, and management options. Among 1019 articles found, 54 articles focusing on treatment/prevention or QoL were retrieved. References of selected articles were also checked manually.
CIA was found to negatively affect QoL and body image, regardless of head covering status (i.e., for cultural or religious reasons). Most studies related to treatment/prevention of CIA reported on the use of scalp-cooling. The efficacy of CAM treatments was found to be questionable.
A high incidence rate of CIA exists with certain chemotherapies, and it significantly impairs QoL. Preventive and treatment strategies are incompletely effective. Additional literature is needed to explore potential preventive or therapeutic options for CIA.
综述关于化疗所致脱发（CIA）管理的现有文献，包括补充和替代医学（CAM），并介绍 CIA 对生活质量（QoL）的影响。
在 9 个数据库中搜索 CIA 相关关键词，包括对 QoL 的影响和管理选择。在 1019 篇文章中，检索到 54 篇重点关注治疗/预防或 QoL 的文章。还手动检查了选定文章的参考文献。
无论是否戴头罩（即出于文化或宗教原因），CIA 均被发现会对 QoL 和身体形象产生负面影响。大多数关于 CIA 治疗/预防的研究都报告了头皮冷却的使用。CAM 治疗的疗效存在疑问。
某些化疗药物会导致 CIA 的发生率较高，且显著降低 QoL。预防和治疗策略并不完全有效。需要更多的文献来探索 CIA 的潜在预防或治疗选择。
