• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

CCT-3的上调通过miR-223竞争和Wnt/β-连环蛋白信号通路激活诱导乳腺癌细胞增殖。

Upregulation of CCT-3 Induces Breast Cancer Cell Proliferation Through miR-223 Competition and Wnt/β-Catenin Signaling Pathway Activation.

作者信息

Qu Hongbo, Zhu Fang, Dong Huaying, Hu Xiongqiang, Han Mingli

机构信息

Department of Breast and Thyroid Surgery, The First People's Hospital of Chenzhou, Chenzhou, China.

Department of Breast Health Center, The First People's Hospital of Chenzhou (South Hospital), Chenzhou, China.

出版信息

Front Oncol. 2020 Sep 24;10:533176. doi: 10.3389/fonc.2020.533176. eCollection 2020.

DOI:10.3389/fonc.2020.533176
PMID:33072568
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7541898/
Abstract

The clinical significance and the function of chaperonin-containing TCP1 complex 3 (CCT-3) in breast cancer remain unknown. In this study, we found that CCT-3 was markedly overexpressed in breast cancer tissues. Statistical analysis revealed a significant correlation of CCT-3 expression with advanced breast cancer clinical stage and poorer survival. Ablation of CCT-3 knocked down the proliferation and the tumorigenicity of breast cancer cells and . CCT-3 may regulate breast cancer cell proliferation through a ceRNA network between miR-223 and β-catenin, thus affecting Wnt/β-catenin signaling pathway activation. We also validated that CCT-3 and β-catenin are novel direct targets of tumor suppressor miR-223. Our results suggest that both mRNA and the protein levels of CCT-3 are potential diagnosis biomarkers and therapeutic targets for breast cancer.

摘要

含TCP1伴侣蛋白复合体3（CCT-3）在乳腺癌中的临床意义及功能尚不清楚。在本研究中，我们发现CCT-3在乳腺癌组织中显著过表达。统计分析显示，CCT-3表达与晚期乳腺癌临床分期及较差的生存率显著相关。敲除CCT-3可降低乳腺癌细胞的增殖和致瘤性。CCT-3可能通过miR-223与β-连环蛋白之间的ceRNA网络调节乳腺癌细胞增殖，从而影响Wnt/β-连环蛋白信号通路的激活。我们还验证了CCT-3和β-连环蛋白是肿瘤抑制因子miR-223的新型直接靶点。我们的结果表明，CCT-3的mRNA和蛋白水平均是乳腺癌潜在的诊断生物标志物和治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ecb/7541898/a181212f00e8/fonc-10-533176-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ecb/7541898/56317bc16413/fonc-10-533176-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ecb/7541898/1df2c0e3c9bd/fonc-10-533176-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ecb/7541898/da23d18d2560/fonc-10-533176-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ecb/7541898/a181212f00e8/fonc-10-533176-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ecb/7541898/56317bc16413/fonc-10-533176-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ecb/7541898/1df2c0e3c9bd/fonc-10-533176-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ecb/7541898/da23d18d2560/fonc-10-533176-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ecb/7541898/a181212f00e8/fonc-10-533176-g0004.jpg

相似文献

1
Upregulation of CCT-3 Induces Breast Cancer Cell Proliferation Through miR-223 Competition and Wnt/β-Catenin Signaling Pathway Activation.CCT-3的上调通过miR-223竞争和Wnt/β-连环蛋白信号通路激活诱导乳腺癌细胞增殖。
Front Oncol. 2020 Sep 24;10:533176. doi: 10.3389/fonc.2020.533176. eCollection 2020.
2
Corrigendum: Upregulation of CCT-3 Induces Breast Cancer Cell Proliferation Through miR-223 Competition and Wnt/b-Catenin Signaling Pathway Activation.勘误：CCT-3的上调通过miR-223竞争和Wnt/β-连环蛋白信号通路激活诱导乳腺癌细胞增殖。
Front Oncol. 2022 May 19;12:917378. doi: 10.3389/fonc.2022.917378. eCollection 2022.
3
MicroRNA-1229 overexpression promotes cell proliferation and tumorigenicity and activates Wnt/β-catenin signaling in breast cancer.微小RNA-1229过表达促进乳腺癌细胞增殖和致瘤性并激活Wnt/β-连环蛋白信号通路。
Oncotarget. 2016 Apr 26;7(17):24076-87. doi: 10.18632/oncotarget.8119.
4
MiR-454-3p-Mediated Wnt/β-catenin Signaling Antagonists Suppression Promotes Breast Cancer Metastasis.miR-454-3p 通过调控 Wnt/β-catenin 信号通路抑制物促进乳腺癌转移。
Theranostics. 2019 Jan 1;9(2):449-465. doi: 10.7150/thno.29055. eCollection 2019.
5
MicroRNA-590-5p functions as a tumor suppressor in breast cancer conferring inhibitory effects on cell migration, invasion, and epithelial-mesenchymal transition by downregulating the Wnt-β-catenin signaling pathway.微小 RNA-590-5p 在乳腺癌中作为一种肿瘤抑制因子发挥作用，通过下调 Wnt-β-连环蛋白信号通路来抑制细胞迁移、侵袭和上皮-间充质转化。
J Cell Physiol. 2019 Feb;234(2):1827-1841. doi: 10.1002/jcp.27056. Epub 2018 Sep 7.
6
MiR-214 negatively regulates proliferation and WNT/β-catenin signaling in breast cancer.微小RNA-214对乳腺癌的增殖和WNT/β-连环蛋白信号通路起负向调控作用。
Eur Rev Med Pharmacol Sci. 2016 Dec;20(24):5148-5154.
7
In vivo and in vitro effects of microRNA-27a on proliferation, migration and invasion of breast cancer cells through targeting of SFRP1 gene via Wnt/β-catenin signaling pathway.微小RNA-27a通过Wnt/β-连环蛋白信号通路靶向SFRP1基因对乳腺癌细胞增殖、迁移和侵袭的体内外作用
Oncotarget. 2017 Feb 28;8(9):15507-15519. doi: 10.18632/oncotarget.14662.
8
SOX30, a target gene of miR-653-5p, represses the proliferation and invasion of prostate cancer cells through inhibition of Wnt/β-catenin signaling.SOX30 是 miR-653-5p 的靶基因，通过抑制 Wnt/β-catenin 信号通路抑制前列腺癌细胞的增殖和侵袭。
Cell Mol Biol Lett. 2019 Dec 23;24:71. doi: 10.1186/s11658-019-0195-4. eCollection 2019.
9
MiR-34a Inhibits Breast Cancer Proliferation and Progression by Targeting Wnt1 in Wnt/β-Catenin Signaling Pathway.微小RNA-34a通过靶向Wnt/β-连环蛋白信号通路中的Wnt1抑制乳腺癌的增殖和进展。
Am J Med Sci. 2016 Aug;352(2):191-9. doi: 10.1016/j.amjms.2016.05.002. Epub 2016 May 7.
10
Downregulation of NRARP exerts anti-tumor activities in the breast tumor cells depending on Wnt/β-catenin-mediated signals: The role of miR-130a-3p.NRARP 的下调通过 Wnt/β-catenin 介导的信号发挥抗肿瘤活性：miR-130a-3p 的作用。
Chem Biol Drug Des. 2022 Sep;100(3):334-345. doi: 10.1111/cbdd.14113. Epub 2022 Jul 14.

引用本文的文献

1
Prognostic Significance of , and Genes in Breast Cancer: Implications for Survival and Therapeutic Stratification.乳腺癌中、和基因的预后意义：对生存及治疗分层的影响
Iran J Biotechnol. 2025 Apr 1;23(2):e4051. doi: 10.30498/ijb.2025.497569.4051. eCollection 2025 Apr.
2
Advances in the study of CCT3 in malignant tumors: A review.CCT3在恶性肿瘤中的研究进展：综述
Medicine (Baltimore). 2025 Feb 7;104(6):e41069. doi: 10.1097/MD.0000000000041069.
3
Chaperonin-containing TCP-1 subunit genes are potential prognostic biomarkers and are correlated with Th2 cell infiltration in lung adenocarcinoma: An observational study.

本文引用的文献

1
Downregulation of miR-223 Expression Is an Early Event during Mammary Transformation and Confers Resistance to CDK4/6 Inhibitors in Luminal Breast Cancer.miR-223 表达下调是乳腺转化早期事件，并赋予 Luminal 乳腺癌对 CDK4/6 抑制剂的抗性。
Cancer Res. 2020 Mar 1;80(5):1064-1077. doi: 10.1158/0008-5472.CAN-19-1793. Epub 2019 Dec 20.
2
Incidence of Late Relapses in Patients With HER2-Positive Breast Cancer Receiving Adjuvant Trastuzumab: Combined Analysis of NCCTG N9831 (Alliance) and NRG Oncology/NSABP B-31.曲妥珠单抗辅助治疗后 HER2 阳性乳腺癌患者的晚期复发发生率：NCCTG N9831（Alliance）与 NRG 肿瘤学/NSABP B-31 的联合分析
J Clin Oncol. 2019 Dec 10;37(35):3425-3435. doi: 10.1200/JCO.19.00443. Epub 2019 Oct 17.
3
热休克蛋白 10 同源蛋白（TCP-1）复合物亚基基因是潜在的预后生物标志物，并与肺腺癌中 Th2 细胞浸润相关：一项观察性研究。
Medicine (Baltimore). 2024 May 31;103(22):e38387. doi: 10.1097/MD.0000000000038387.
4
G2/M Checkpoint Modulation: Insights from miRNA Profiles in FAM and Breast Cancer.G2/M 检查点调控：微小 RNA 谱在 FAM 和乳腺癌中的研究进展。
Asian Pac J Cancer Prev. 2024 Aug 1;25(8):2661-2668. doi: 10.31557/APJCP.2024.25.8.2661.
5
Exploring Prognostic Gene Factors in Breast Cancer via Machine Learning.通过机器学习探索乳腺癌的预后基因因素。
Biochem Genet. 2024 Dec;62(6):5022-5050. doi: 10.1007/s10528-024-10712-w. Epub 2024 Feb 21.
6
Revisiting the chaperonin T-complex protein-1 ring complex in human health and disease: A proteostasis modulator and beyond.重新审视热休克蛋白 T 复合物蛋白-1 环复合物在人类健康和疾病中的作用：一种蛋白质稳态调节剂及其以外的作用。
Clin Transl Med. 2024 Feb;14(2):e1592. doi: 10.1002/ctm2.1592.
7
A potential tumor marker: Chaperonin containing TCP‑1 controls the development of malignant tumors (Review).一种潜在的肿瘤标志物：热休克蛋白 10 家族成员 1 调控恶性肿瘤的发生发展（综述）。
Int J Oncol. 2023 Sep;63(3). doi: 10.3892/ijo.2023.5554. Epub 2023 Aug 4.
8
Insights into the roles and driving forces of CCT3 in human tumors.深入了解CCT3在人类肿瘤中的作用及驱动因素。
Front Pharmacol. 2022 Oct 12;13:1005855. doi: 10.3389/fphar.2022.1005855. eCollection 2022.
9
Current understanding on the role of CCT3 in cancer research.目前对CCT3在癌症研究中作用的认识。
Front Oncol. 2022 Sep 15;12:961733. doi: 10.3389/fonc.2022.961733. eCollection 2022.
10
Circular RNA circLRCH3 Inhibits Proliferation, Migration, and Invasion of Colorectal Cancer Cells Through miRNA-223/LPP Axis.环状RNA circLRCH3通过miRNA-223/LPP轴抑制结肠癌细胞的增殖、迁移和侵袭。
Onco Targets Ther. 2022 May 18;15:541-554. doi: 10.2147/OTT.S366605. eCollection 2022.
MiR-223-3p targeting epithelial cell transforming sequence 2 oncogene inhibits the activity, apoptosis, invasion and migration of MDA-MB-468 breast cancer cells.靶向上皮细胞转化序列2癌基因的MiR-223-3p抑制MDA-MB-468乳腺癌细胞的活性、凋亡、侵袭和迁移。
Onco Targets Ther. 2019 Sep 18;12:7675-7684. doi: 10.2147/OTT.S217019. eCollection 2019.
4
CCT α is a novel biomarker for diagnosis of laryngeal squamous cell cancer.CCTα 是一种用于诊断喉鳞状细胞癌的新型生物标志物。
Sci Rep. 2019 Aug 14;9(1):11823. doi: 10.1038/s41598-019-47895-x.
5
Targeting β-tubulin/CCT-β complex induces apoptosis and suppresses migration and invasion of highly metastatic lung adenocarcinoma.靶向β-微管蛋白/CCT-β 复合物诱导高转移性肺腺癌细胞凋亡并抑制其迁移和侵袭。
Carcinogenesis. 2020 Jul 10;41(5):699-710. doi: 10.1093/carcin/bgz137.
6
Global Consultation on Cancer Staging: promoting consistent understanding and use.全球癌症分期共识会议：促进一致理解和应用。
Nat Rev Clin Oncol. 2019 Dec;16(12):763-771. doi: 10.1038/s41571-019-0253-x. Epub 2019 Aug 6.
7
Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma.蛋白激酶 Cι 和 Wnt/β-连环蛋白信号通路：Kras/Trp53 驱动的肺腺癌的另一种途径。
Cancer Cell. 2019 Aug 12;36(2):156-167.e7. doi: 10.1016/j.ccell.2019.07.002. Epub 2019 Aug 1.
8
Long noncoding RNA promotes autophagy and apoptosis via sponging and in high glucose-induced vascular endothelial cells.长链非编码 RNA 通过海绵作用和在高糖诱导的血管内皮细胞中促进自噬和凋亡。
Autophagy. 2020 Jan;16(1):70-85. doi: 10.1080/15548627.2019.1598750. Epub 2019 Apr 7.
9
LncIRS1 controls muscle atrophy via sponging miR-15 family to activate IGF1-PI3K/AKT pathway.长链非编码 RNA IRS1 通过海绵吸附 miR-15 家族来激活 IGF1-PI3K/AKT 通路，从而控制肌肉萎缩。
J Cachexia Sarcopenia Muscle. 2019 Apr;10(2):391-410. doi: 10.1002/jcsm.12374. Epub 2019 Jan 30.
10
Extracellular Vesicles from Neurosurgical Aspirates Identifies Chaperonin Containing TCP1 Subunit 6A as a Potential Glioblastoma Biomarker with Prognostic Significance.神经外科抽吸液中的细胞外囊泡鉴定热休克蛋白 10 家族成员 6A 作为具有预后意义的潜在胶质母细胞瘤生物标志物。
Proteomics. 2019 Jan;19(1-2):e1800157. doi: 10.1002/pmic.201800157.