Institute of Endocrinology and Nutrition, Medicine School and Department of Endocrinology and Investigation, Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain,
Institute of Endocrinology and Nutrition, Medicine School and Department of Endocrinology and Investigation, Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain.
Lifestyle Genom. 2020;13(6):164-171. doi: 10.1159/000508819. Epub 2020 Oct 19.
The role of adiponectin (ADIPOQ) polymorphisms in weight loss and serum lipid changes following different dietary interventions remain unclear. The Mediterranean dietary pattern has been associated with improved cardiovascular risk factors in different studies.
Our aim was to analyze the effects of a hypocaloric diet with a Mediterranean dietary pattern on the metabolic response and adiposity parameters, taking into account the 712 G/A rs3774261 polymorphisms in ADIPOQ.
A population of 135 obese patients was enrolled. Anthropometric and serum parameters (lipid profile, insulin, homeostasis model assessment for insulin resistance [HOMA-IR], glucose, C-reactive protein [CRP], adiponectin, resistin, and leptin levels) were measured before and after the dietary intervention (12 weeks). All of the patients were genotyped for the rs3774261 polymorphism.
The genotype distribution of this population was 36 patients with AA (26.7%), 68 patients with AG (50.4%), and 31 patients with GG (22.9%). After the dietary intervention and in both genotypes, BMI, weight, fat mass, systolic blood pressure, waist circumference, glucose, insulin, HOMA-IR, and leptin levels all decreased. After the dietary intervention with secondary weight loss and in non-G-allele carriers (AA vs. AG+GG), total cholesterol (Δ = -15.7 ± 3.9 vs. -4.9 ± 2.9 mg/dL; p = 0.02), LDL cholesterol (Δ = -15.3 ± 3.8 vs. -1.7 ± 1.9 mg/dL; p = 0.01), triglyceride levels (Δ = -23.4 ± 5.6 vs. 2.3 ± 2.3 mg/dL; p = 0.01), and CRP (Δ = -1.1 ± 0.1 vs. -0.4 ± 0.2 mg/dL; p = 0.01) decreased. Adiponectin levels (Δ = 7.2 ± 2.1 vs. -0.4 ± 0.3 ng/dL; p = 0.02) increased. Notably, G-allele carriers did not show this improvement.
Non-G-allele carriers of the ADIPOQ variant (rs3774261) showed significant improvement in serum levels of adiponectin, lipid profiles, and CRP in response to a hypocaloric diet with a Mediterranean dietary pattern.
脂联素（ADIPOQ）多态性在不同饮食干预下的体重减轻和血清脂质变化中的作用尚不清楚。地中海饮食模式已被证明可改善不同研究中的心血管危险因素。
我们旨在分析低热量饮食结合地中海饮食模式对代谢反应和肥胖参数的影响，同时考虑 ADIPOQ 中的 712 G/A rs3774261 多态性。
招募了 135 名肥胖患者。在饮食干预（12 周）前后测量了人体测量和血清参数（血脂谱、胰岛素、稳态模型评估的胰岛素抵抗 [HOMA-IR]、血糖、C 反应蛋白 [CRP]、脂联素、抵抗素和瘦素水平）。所有患者均进行了 rs3774261 多态性的基因分型。
该人群的基因型分布为 36 例 AA（26.7%）、68 例 AG（50.4%）和 31 例 GG（22.9%）。在饮食干预后，在两种基因型中，BMI、体重、脂肪量、收缩压、腰围、血糖、胰岛素、HOMA-IR 和瘦素水平均降低。在低热量饮食结合继发性体重减轻和非 G 等位基因携带者（AA 与 AG+GG）中，总胆固醇（Δ=-15.7±3.9 与-4.9±2.9 mg/dL；p=0.02）、低密度脂蛋白胆固醇（Δ=-15.3±3.8 与-1.7±1.9 mg/dL；p=0.01）、甘油三酯水平（Δ=-23.4±5.6 与 2.3±2.3 mg/dL；p=0.01）和 CRP（Δ=-1.1±0.1 与-0.4±0.2 mg/dL；p=0.01）降低。脂联素水平（Δ=7.2±2.1 与-0.4±0.3 ng/dL；p=0.02）升高。值得注意的是，G 等位基因携带者没有表现出这种改善。
ADIPOQ 变异（rs3774261）的非 G 等位基因携带者在接受低热量饮食结合地中海饮食模式后，血清脂联素、血脂谱和 CRP 水平显著改善。
