Center of Investigation of Endocrinology and Nutrition, Medicine School and Dept. of Endocrinology and Investigation. Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain.
Dis Markers. 2022 Jan 25;2022:7058389. doi: 10.1155/2022/7058389. eCollection 2022.
rs822393 (-4522C/T) genetic variant is associated with hypoadiponectinemia and other metabolic parameters. The aim of our investigation was to analyze the effects of a hypocaloric diet with Mediterranean dietary pattern during 9 months according to genetic variant rs822393 of gene.
A sample of 269 obese patients was enrolled. Anthropometric and serum parameters (lipid profile, insulin, homeostasis model assessment (HOMA-IR), glucose, C reactive protein, and adipokines) were determined, at basal time and after 3 and 9 months. All patients were genotyped in the rs822393. The genotype distribution was as follow; 176 patients (65.4%) CC, 83 patients CT (30.9%), and 10 patients TT (3.7%). After dietary intervention, the following parameters improved in non-T allele carriers; BMI, weight, fat mass, waist circumference, systolic blood pressure, insulin levels, HOMA-IR, leptin, total cholesterol, and LDL-cholesterol improved significantly. HDL-cholesterol (delta: 5.7 ± 1.1 mg/dl vs. 1.0 ± 0.8 mg/dl; = 0.01), serum adiponectin (delta: 14.4 ± 2.0 ng/dl vs. 7.1 ± 3.1 ng/dl; = 0.02), and adiponectin/leptin ratio (delta: 0.54 ± 0.1 vs. 0.22 ± 0.09 ng/dl; = 0.03). Basal and postintervention HDL cholesterol, adiponectin levels, and adiponectin/leptin levels were lower in T-allele carriers than non-T Allele carriers.
T allele carriers showed lower levels of HDL-cholesterol, adiponectin, and adiponectin/leptin ratio than non-T allele carriers. A medium-term hypocaloric diet with a Mediterranean partner increased adiponectin levels, ratio adiponectin/leptin, and HDL-cholesterol in non-T allele carriers.
rs822393（-4522C/T）基因变异与低脂联素血症和其他代谢参数有关。我们的研究目的是分析 9 个月内低热量饮食与地中海饮食模式对基因 rs822393 变异的影响。
共纳入 269 名肥胖患者。在基础时间和 3 个月和 9 个月后，测定了患者的人体测量和血清参数（血脂谱、胰岛素、稳态模型评估（HOMA-IR）、血糖、C 反应蛋白和脂肪因子）。所有患者均进行了 rs822393 基因分型。基因型分布如下：176 名患者（65.4%）为 CC 型，83 名患者为 CT 型（30.9%），10 名患者为 TT 型（3.7%）。饮食干预后，非 T 等位基因携带者的以下参数改善：BMI、体重、脂肪量、腰围、收缩压、胰岛素水平、HOMA-IR、瘦素、总胆固醇和 LDL 胆固醇显著改善。HDL 胆固醇（差值：5.7±1.1mg/dl 比 1.0±0.8mg/dl；=0.01）、血清脂联素（差值：14.4±2.0ng/dl 比 7.1±3.1ng/dl；=0.02）和脂联素/瘦素比值（差值：0.54±0.1 比 0.22±0.09ng/dl；=0.03）升高。T 等位基因携带者的基础和干预后 HDL 胆固醇、脂联素水平和脂联素/瘦素比值均低于非 T 等位基因携带者。
T 等位基因携带者的 HDL 胆固醇、脂联素和脂联素/瘦素比值均低于非 T 等位基因携带者。地中海饮食模式的中短期低热量饮食可增加非 T 等位基因携带者的脂联素水平、脂联素/瘦素比值和 HDL 胆固醇。
