来自一株人源乳酸杆菌的抗菌物质。
Antimicrobial substance from a human Lactobacillus strain.
作者信息
Silva M, Jacobus N V, Deneke C, Gorbach S L
出版信息
Antimicrob Agents Chemother. 1987 Aug;31(8):1231-3. doi: 10.1128/AAC.31.8.1231.
Abstract
Lactobacillus sp. strain GG, which was isolated from the feces of a normal person, produced a substance with potent inhibitory activity against a wide range of bacterial species. It inhibited anaerobic bacteria (Clostridium spp., Bacteroides spp., Bifidobacterium spp.), members of the family Enterobacteriaceae, Pseudomonas spp. Staphylococcus spp., and Streptococcus spp., as demonstrated by a microbiological assay; however, it did not inhibit other lactobacilli. The inhibitory activity occurred between pH 3 and 5 and was heat stable. Bactericidal activity against Escherichia coli was demonstrated at a dilution of 1:128. The inhibitory substance was distinct from lactic and acetic acids. It had a low molecular weight (less than 1,000) and was soluble in acetone-water (10:1). Because of these characteristics, the inhibitory material could not be considered a bacteriocin; it most closely resembled a microcin, which has been associated previously with members of the family Enterobacteriaceae.
摘要
从正常人粪便中分离出的嗜酸乳杆菌GG菌株产生了一种对多种细菌具有强效抑制活性的物质。通过微生物检测表明，它能抑制厌氧菌（梭菌属、拟杆菌属、双歧杆菌属）、肠杆菌科成员、假单胞菌属、葡萄球菌属和链球菌属；然而，它并不抑制其他乳酸杆菌。抑制活性出现在pH 3至5之间，且具有热稳定性。在1:128的稀释度下对大肠杆菌表现出杀菌活性。该抑制物质与乳酸和乙酸不同。它具有低分子量（小于1000），可溶于丙酮 - 水（10:1）。由于这些特性，该抑制物质不能被认为是一种细菌素；它与微菌素最为相似，微菌素此前已与肠杆菌科成员相关联。
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