The 940 Hospital of Joint Logistic Support Force of PLA, Lanzhou, 730050, China.
Huoshenshan Hospital, Wuhan, 430050, China.
BMC Infect Dis. 2020 Oct 19;20(1):771. doi: 10.1186/s12879-020-05480-y.
COVID-19 is novel infectious disease with an evolving understanding of its epidemiology and clinical manifestations. Severe cases developed life-threatening complications, such as respiratory failure, shock, and multiple organs dysfunction. Immunocompromised patients often present atypical presentations of viral infected diseases.
We report newly diagnosed HIV infections in two patients with COVID-19 in China. In our two cases, both patients with elevated IL-6 received Tocilizumab treatment, but did not present obvious therapeutic effect.
These cases highlight possible co-detection of known immunocompromised diseases such as HIV. The two cases we reported stressed the risk of misdiagnosis, especially during the pandemic of an infectious disease and the importance of extended testing even if in immune-compromised condition the immune state may be ignored.
COVID-19 是一种新型传染病，其流行病学和临床表现的认识在不断发展。严重病例出现危及生命的并发症，如呼吸衰竭、休克和多器官功能障碍。免疫功能低下的患者常表现出病毒性感染疾病的非典型表现。
我们报告了在中国 COVID-19 患者中发现的两例新诊断的 HIV 感染。在我们的两个病例中，两名白细胞介素 6 升高的患者均接受了托珠单抗治疗，但未呈现明显的治疗效果。
这些病例强调了可能同时检测到已知免疫功能低下疾病，如 HIV。我们报告的这两个病例强调了误诊的风险，尤其是在传染病大流行期间，即使在免疫功能低下的情况下，也需要进行扩展检测，因为免疫状态可能被忽视。
